【摘要】 N~6-甲基腺苷（m~6A）阅读器通过识别RNA上的m~6A修饰，调控转录后基因表达，在乳腺癌发生发展中发挥关键作用。本文系统综述了YT521-B同源性（YTH）结构域家族、胰岛素样生长因子2 mRNA结合蛋白（IGF2BP）家族和异质性胞核核糖核蛋白（HNRNP）家族等m~6A阅读器调控乳腺癌增殖、转移及治疗抵抗的分子机制，并探讨靶向这些阅读器的潜在治疗策略，以期为深入理解乳腺癌进展机制及开发新型干预手段提供参考。更多还原

【Abstract】 China ABSTRACT N~6-methyladenosine(m~6A) readers play critical roles in breast cancer progression by recognizing m~6A modifications on RNA and regulating post-transcriptional gene expression. This review systematically summarizes the molecular mechanisms by which m~6A readers(including YTH domain family, IGF2BPs, and HNRNP family) regulate breast cancer proliferation, metastasis, and therapy resistance, while exploring potential therapeutic strategies targeting these readers. The findings may provide valuable insights for understanding breast cancer progression mechanisms and developing novel interventions.更多还原