【摘要】 不可切除肝细胞癌（u-HCC）是全球肿瘤治疗的难题，其发病主要与慢性乙型病毒性肝炎、慢性丙型病毒性肝炎以及非酒精性脂肪肝等疾病相关。传统单学科诊疗往往难以全面评估肿瘤负荷、肝功能储备与患者全身状态，治疗效果有限。多学科协作（MDT）模式通过整合外科、肿瘤内科、介入科、影像科、病理科及肝病科等多方资源，推动实现个体化全程管理。现有证据显示，MDT可显著延长患者中位总生存期，提高转化切除率，并减少治疗相关不良事件，对高危亚组如门静脉癌栓、Child-Pugh B级和老年患者也明确有益。MDT不仅是现代国际医疗领域广为推崇的领先诊疗模式，也为复杂肿瘤诊疗提供借鉴。然而，MDT的临床推广仍面临资源分布不均、标准缺乏和政策支持不足等挑战。未来应致力于构建基于多组学和人工智能的精准决策体系，建立全周期管理路径，并在统一框架下推进区域化和国际化实践。更多还原

【Abstract】 Unresectable hepatocellular carcinoma(u-HCC) is a global challenge in cancer treatment, and its pathogenesis is mainly associated with chronic hepatitis B, chronic hepatitis C, and non-alcoholic fatty liver disease and other diseases. Traditional single-discipline diagnosis and treatment often fail to comprehensively access tumor burden, liver function reserve, and the overall condition of patients, resulting in limited therapeutic effects. The multidisciplinary team(MDT) model integrates resources from multiple departments, including surgery, medical oncology, interventional radiology, radiology, pathology and hepatology, to promote personalized full process management. Existing evidence has showed that MDT could significantly prolong the median overall survival of patients, improve the conversion resection rate, and reduce treatment-related adverse events. It also has clear benefits for high-risk subgroups such as portal vein thrombosis, Child-Pugh grade B, and elderly patients. MDT is not only a leading diagnostic and treatment model widely respected in the modern international medical field, but also provides a reference for the diagnosis and treatment of complex tumors. However, the clinical popularization of MDT still faces challenges such as uneven resource distribution, lack of standards, and insufficient policy support. In the future, efforts should be made to build a precise decision-making system based on multi-omics and artificial intelligence, establish a full-cycle management pathway, and promote regional and international practices under a unified framework.更多还原