【摘要】 目的 探讨舒血宁注射液联合盐酸替罗非班氯化钠注射液对急性脑梗死(ACI)患者神经功能、氧化应激反应的治疗效果。方法 选取许昌市人民医院2022年5月至2025年3月收治的91例ACI患者作为研究对象，依照治疗方案不同分为对照组(46例)、观察组(45例)。对照组采用盐酸替罗非班氯化钠注射液治疗，观察组在对照组基础上加用舒血宁注射液治疗。比较两组临床疗效、神经功能[美国国立卫生研究院卒中量表(NIHSS)评分]、氧化应激反应[丙二醛(MDA)、超氧化物歧化酶(SOD)、8-羟基脱氧鸟苷(8-OHdG)]、神经血管单元功能[血管内皮生长因子(VEGF-A)、基质金属蛋白酶-9(MMP-9)、紧密连接蛋白-5(Claudin-5)]、不良反应。结果 治疗后，观察组临床总有效率高于对照组(P<0.05)；观察组NIHSS评分较对照组低(P<0.05)；观察组MDA、8-OHdG、MMP-9水平均低于对照组，SOD、VEGF-A、Claudin-5水平均高于对照组(P<0.05)。治疗期间两组不良反应总发生率比较，差异无统计学意义(P>0.05)。结论 舒血宁注射液联合盐酸替罗非班氯化钠注射液应用于ACI患者，可减轻神经缺损程度，提高临床疗效，减轻氧化应激损伤，保护神经血管单元功能，且安全性良好。更多还原

【Abstract】 Objective To explore the therapeutic effect of shuxuening injection combined with tirofiban hydrochloride and sodium chloride injection on neurological function and oxidative stress response in patients with acute cerebral infarction (ACI).Methods A total of 91 patients with ACI who were admitted to Xuchang People’s Hospital from May 2022 to March 2025 were selected as the study subjects and divided into a control group (46 cases) and an observation group (45 cases) according to different treatment regimens.The control group was treated with tirofiban hydrochloride and sodium chloride injection,while the observation group received additional shuxuening injection on the basis of the control group.The clinical efficacy,neurological function[national institutes of health stroke scale (NIHSS) scores],oxidative stress response[malondialdehyde (MDA),superoxide dismutase (SOD),8-hydroxydeoxyguanosine (8-OHdG)],neurovascular unit function[vascular endothelial growth factor (VEGF-A),matrix metalloproteinase-9 (MMP-9),Claudin-5],and adverse reactions were compared between the two groups.Results After treatment,the total clinical effective rate of the observation group was higher than that of the control group (P<0.05);the NIHSS scores in the observation group decreased than in the control group (P<0.05);the MDA,8-OHdG,and MMP-9 levels in the observation group were all lower than those in the control group,while SOD,VEGF-A,and Claudin-5 levels were all higher than those in the control group (P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups during the treatment period (P>0.05).Conclusion The combination of shuxuening injection and tirofiban hydrochloride and sodium chloride injection in patients with ACI can reduce the degree of neurological deficit,improve clinical efficacy,alleviate oxidative stress damage,protect the function of neurovascular units,and has good safety.更多还原