【摘要】 以2-氨基苯并咪唑为原料，对其胺基进行保护后通过碳氮偶联、卤代烃反应制备TRPC5抑制剂AC1903衍生物。采用核磁共振氢谱和高分辨质谱确认目标化合物结构，最终成功得到AC1903衍生物4a～c。此合成路线的反应条件温和可控，收率较高，为后续治疗慢性肾脏疾病的相关实验研究奠定基础。更多还原

【Abstract】 A kind of TRPC5 inhibitor AC1903 derivative was prepared by carbon-nitrogen coupling and halogenated hydrocarbon reaction after the amino group of 2-aminobenzimidazole was protected. The structure of the target compound was confirmed by nuclear magnetic resonance spectroscopy and high resolution mass spectrometry. Finally, AC1903 derivative 4a-c was successfully obtained. The reaction conditions of this synthetic route are mild and controllable, and the yield is high, which lays a foundation for the subsequent experimental research on the treatment of chronic kidney disease.更多还原