【摘要】 目的 探讨5例宫颈腺样基底细胞癌（ABC）的临床病理特点、免疫组化特征、诊断、鉴别诊断、治疗方式和预后，以期为临床病理诊断提供参考。方法 选取2019年10月至2024年9月于我院病理科确诊的5例ABC患者，通过宫颈液基薄层细胞学检查（TCT）、人乳头瘤病毒（HPV）分型检测、组织病理学检查、免疫组化染色等方法，分析肿瘤的组织学形态、免疫组化特征、鉴别诊断及预后，并结合相关文献讨论。结果 5例患者的年龄51～72岁，平均年龄（58.20±8.60）岁。在TCT检查中，3例提示高级别鳞状上皮内病变（HSIL）。5例患者HPV检测均为高危阳性。镜下观察见基底样肿瘤细胞巢，外围细胞呈栅栏状排列，部分巢中央由腺样或筛样细胞构成，部分癌巢可见鳞状分化。免疫组化显示P16、P40为弥漫阳性，外层基底样细胞P63阳性，腺样或筛样结构内层腺上皮表达CK5/6、部分表达NKX3.1。结论 ABC是一种罕见的宫颈癌类型，总体预后良好。ABC具有较典型的临床病理特征，免疫组化检测有助于其诊断与鉴别诊断。更多还原

【Abstract】 Objective To investigate the clinicopathological features, immunohistochemical features, diagnosis,differential diagnosis, treatment and prognosis of 5 cases of adenoid basal carcinoma(ABC), so as to provide reference for clinicopathological diagnosis. Methods Five patients with ABC diagnosed in the pathology department of our hospital from October 2019 to September 2024 were selected, the histological morphology,immunohistochemical characteristics, differential diagnosis and prognosis of the tumors were analyzed by cervical thinprep cytology test(TCT), human papillomavirus(HPV) typing, histopathological examination and immunohistochemical staining, and discussed in combination with relevant literature. Results The age of the5 patients ranged from 51 to 72 years, with an average age of(58.20±8.60) years. In TCT examination, 3 cases showed high-grade squamous intraepithelial lesion(HSIL). All of the 5 patients were high-risk HPV positive.Microscopically, basal-like tumor cell nests were observed, and peripheral cells were arranged in a fencelike manner, some nests were composed of adenoid or cribriform cells in the center, and squamous differentiation was observed in some cancer nests. Immunohistochemistry showed that P16 and P40 were diffusely positive,P63 was positive in outer basal-like cells, CK5/6 was expressed in inner glandular epithelium of adenoid or cribriform structure, and NKX3.1 was partially expressed. Conclusion ABC is a rare type of cervical cancer with a good overall prognosis. The ABC has typical clinicopathological features, and immunohistochemical detection is helpful for its diagnosis and differential diagnosis.更多还原