【摘要】 目的 了解四川省凉山州艾滋病某高流行县单阳家庭阴性配偶对nPEP用药的使用意愿及影响因素，为制定针对该人群的艾滋病暴露后预防用药策略提供科学依据。方法 采用横断面调查的方法抽取四川省凉山州某艾滋病高流行县单阳家庭阴性配偶进行面对面问卷调查，收集调查对象一般情况、艾滋病知识知晓情况、性行为特征、nPEP相关知识知晓情况及使用意愿等信息，采用Logistic回归模型分析单阳家庭阴性配偶的nPEP用药相关影响因素。结果 本研究共收集有效问卷387份，其中有270名（69.77%）调查对象表示愿意使用暴露后预防用药。仅有68名（17.57%）调查对象正确回答nPEP用途，1名正确回答nPEP适用时间。多因素Logistic回归分析结果显示，阳性配偶身体状况很好（aOR=2.123,95%CI:1.155～3.903）、性行为频率小于5次/月（2～4次/月：aOR=2.504,95%CI:1.201～5.221;1次及以下/月：aOR=3.219,95%CI:1.483～6.990）以及最近3个月与配偶发生性行为经常使用安全套（aOR=5.200,95%CI:1.510～17.914）的调查对象接受nPEP的意愿更高。结论 凉山州单阳家庭阴性配偶对艾滋病nPEP用药的使用及推广持积极态度，但缺乏nPEP用药的相关知识。应加强nPEP知识普及，并对性行为频率较高与安全套使用不规律的群体开展针对性宣传。更多还原

【Abstract】 Objective To examine the willingness to use non-occupational post-exposure prophylaxis(nPEP) and its influencing factors among human immunodeficiency virus(HIV) negative spouses in serodiscordant couples in the Liangshan Yi Autonomous Prefecture(Liangshan) of Sichuan Province and to provide a scientific basis for developing targeted n PEP strategies for this population. Methods A face-to-face questionnaire survey was conducted among 387 HIV negative spouses in serodiscordant couples selected from several high-HIVprevalence townships in Liangshan, Sichuan Province. Demographic data, sexual behavior, awareness, and willingness regarding nPEP were collected. Logistic regression models were used to analyze the factors influencing nPEP use. Results In total, 387 valid questionnaires were collected, of which 270(69.77%) expressed a willingness to use nPEP. Only 68 respondents(17.57%) correctly noted the purpose of nPEP, and only one respondent correctly answered regarding its timing. The multivariate logistic analysis results showed that the participants whose spouses are HIV positive were physically healthy [adjusted odds ratio(aOR)=2.123, 95% confidence interval(CI): 1.155-3.903], those with a lower frequency of sexual intercourse(2-4 times/month: aOR=2.504, 95%CI: 1.201-5.221; ≤1 time/month: aOR=3.219, 95%CI: 1.483-6.990), and those who typically used condoms in the past 3 months(aOR=5.200, 95%CI: 1.510-17.914) were more willing to use n PEP. Conclusions HIV negative serodiscordant couples in Liangshan generally held positive attitudes toward nPEP use. However, nPEP related knowledge in this population remains understudied. Efforts should be strengthened to disseminate n PEP knowledge through targeted outreach to populations engaged in frequent sexual intercourse and inconsistent condom use.更多还原