【摘要】 目的 探究尿微量白蛋白/肌酐比值（albumin to creatinine ratio, ACR）、β2-微球蛋白（β2-microglobulin,β2-MG）、视黄醇结合蛋白（retinol binding protein, RBP）及血肌酐（creatinine, CREA）在糖尿病肾病（diabetic nephropathy, DN）早期肾损伤诊断中的价值。方法 回顾性选取2023年9月—2025年6月青岛市胶州中心医院就诊的100例DN患者的临床资料作为观察组，并同期收集89例单纯糖尿病患者的临床资料作为对照组。检测ACR、β2-MG、RBP、CREA水平，对比两组上述指标水平差异，并分析各指标单独及联合检测对DN早期肾损伤的诊断效能。结果 观察组ACR、β2-MG、RBP、CREA均高于对照组，差异均有统计学意义（P均<0.05）。联合检测的诊断灵敏度、特异度、准确度、阳性预测值、阴性预测值均高于单一指标检测，差异均有统计学意义（P均<0.05）。结论 ACR、β2-MG、RBP、CREA均能在一定程度上反映DN患者早期肾损伤情况，且4项指标联合检测可提高诊断效能，为DN早期诊断提供更可靠的依据。更多还原

【Abstract】 Objective To explore the application value of albumin to creatinine ratio(ACR), β2-microglobulin(β2-MG), retinol binding protein(RBP) and serum creatinine(CREA) in the diagnosis of early renal injury in diabetic nephropathy(DN). Methods The clinical data of 100 DN patients treated in Jiaozhou Central Hospital in Qingdao City from September 2023 to June 2025 were retrospectively selected as the observation group, and the clinical data of 89 simple diabetes patients were collected as the control group at the same time. The levels of ACR, β2-MG, RBP and CREA were detected, the differences in the above indicators between the two groups were compared, and the diagnostic efficacy of each indicator alone and in combination for the early renal injury in DN was analyzed. Results The levels of ACR, β2-MG, RBP and CREA in the observation group were higher than those in the control group, and the differences were statistically significant(all P<0.05). The diagnostic sensitivity, specificity, accuracy, positive predictive value and negative predictive value of the combined detection were higher than those of the single indicator detection, and the differences were statistically significant(all P<0.05). Conclusion ACR, β2-MG, RBP and CREA can all reflect the early renal injury in DN patients to a certain extent, and the combined detection of the four indicators can significantly improve the diagnostic efficacy, providing a more reliable basis for the early diagnosis of DN.更多还原