【摘要】 目的 分析宿迁市2013-2022年恙虫病的临床特征及流行病学特征，为制定有效的恙虫病防治策略提供科学依据。方法 收集2013年1月-2022年12月徐州医科大学附属宿迁医院收治的504例恙虫病患者的临床资料，包括基本信息、临床症状及体征、实验室检查结果和治疗方案。采用描述性流行病学方法进行分析。结果 504例患者中，男女比例为1∶1.99，平均年龄（58.29±14.88）岁，农民占83.53%；发病集中在10和11月，病例主要分布在宿豫区（210例）和宿城区（235例）。恙虫病患者年龄主要集中在50～<60岁、60～<70岁年龄组，均为女性多于男性。主要症状为发热（100.00%）、焦痂或溃疡（91.47%）、淋巴结肿大（63.69%）、肌肉酸痛或乏力（63.89%）等。实验室检查显示白细胞及嗜酸性粒细胞计数异常、C反应蛋白升高等，影像学检查发现部分患者有胸腔积液、脾肿大等。经阿奇霉素或多西环素治疗，治愈率为99.40%(501/504)。结论 宿迁市恙虫病流行具有明显季节性、性别和年龄分布特点，通过加强宣传教育后，发病率已有所下降。未来需持续关注流行动态，优化防治策略。更多还原

【Abstract】 Objective To analyze the epidemiological characteristics of scrub typhus in Suqian city, from 2013 to 2022, and provide a scientific basis for the local development of effective prevention and control strategies for the disease. Methods Clinical data of 504 scrub typhus patients treated at the Affiliated Suqian Hospital of Xuzhou Medical University from January 2013 to December 2022 were collected. This included basic information, clinical symptoms and signs, laboratory test results and treatment plans. Descriptive epidemiological methods were used for the analysis. Results Among the 504 patients, the male to female ratio was 1∶1.99, with an average age of(58.29±14.88) years, and 83.53% were farmers. Onset of the disease was concentrated in October and November, and the cases were mainly distributed in Suyu district(210 cases) and Sucheng district(235 cases). The patients were mainly in the 50-<60 and 60-<70 age groups, more women than men. The main symptoms were fever(100.00%), eschar or ulcer(91.47%), lymphadenopathy(63.69%), and myalgia or fatigue(63.89%). Laboratory tests showed abnormal white blood cell and eosinophil counts, elevated C-reactive protein, etc. Imaging examinations revealed that some patients had pleural effusion, splenomegaly, and so on. After treatment with azithromycin or doxycycline, the cure rate was 99.40%(501/504). Conclusions The prevalence of scrub typhus in Suqian city exhibited distinct seasonal, gender and age distribution patterns. Following enhanced public health education efforts by our research team, the incidence rate had shown a decline. Continued monitoring of epidemiological trends and optimization of prevention strategies remain essential in the future.更多还原