【摘要】 利用5项改良衰弱指数(5-mFI)预测老年腹腔镜结直肠癌根治术并发症。将患者分为非衰弱组(<2分，n=80)和衰弱组(≥2分，n=40),发现衰弱组术后胃肠道并发症发生率显著高于非衰弱组(P<0.05),且风险随5-mFI评分升高递增(P<0.01)。Lasso回归初筛后经多因素分析最终确定5-mFI、术中出血量、身体质量指数(BMI)及阳性淋巴结数为独立危险因素(均P<0.05)。基于此构建的列线图模型训练集AUC达0.9355,Bootstrap验证后AUC为0.8705。判定5-mFI评分是老年结直肠癌患者行腹腔镜下结直肠根治术后并发症的预测因素，随着5-mFI评分的增加，老年结直肠癌患者术后发生胃肠道并发症的风险越高。更多还原

【Abstract】 This study aims to clarify the relationship between the combined index score based on the five-item modified frailty index(5-mFI) and complications of laparoscopic radical resection for colorectal cancer in elderly patients.According to the 5-mFI,patients were divided into a non-frail group(<2 points, n=80) and a frail group(≥2 points, n=40).The incidence of postoperative gastrointestinal complications in the frail group was significantly higher than that in the non-frail group(P<0.05),and the risk increased with higher 5-mFI scores(P<0.01).After initial screening with Lasso regression and further multivariate analysis, 5-mFI,intraoperative blood loss, BMI,and the number of positive lymph nodes were identified as independent risk factors(all P<0.05).The AUC of the nomogram model constructed based on this reached 0.9355 in the training set, and the AUC after Bootstrap validation was 0.8705.The 5-mFI score is a predictive factor for complications after laparoscopic radical resection in elderly colorectal cancer patients; as the 5-mFI score increases, the risk of postoperative gastrointestinal complications in elderly colorectal cancer patients increases.更多还原