【摘要】 目的 探讨中枢神经细胞瘤(CNC)的流行病学、病理特点，治疗方法及其临床疗效。方法 回顾性分析深圳市第二人民医院神经外科2016年2月—2023年2月手术治疗的13例CNC患者的临床特征、影像特征、手术方式、总存活率和无进展存活率，并分析随访结果。结果 手术全切11例，次全切2例，其中采用显微镜下经皮质入路10例，全神经内镜手术3例。术后2例出现脑积水，1例保守治疗后自行好转，1例行脑室-腹腔分流术后明显好转；1例出现右侧肢体偏瘫，经康复治疗后改善；1例术后1 h出现急性硬膜外血肿行手术治疗；术后放疗4例，术后随访9～93个月，复发1例。结论 最大范围安全切除是CNC主要治疗方式，完全切除后不建议辅助放射治疗，对于肿瘤不完全切除的患者，术后辅助放射治疗可改善患者的预后。更多还原

【Abstract】 Objective To discuss the epidemiology, pathological features, treatment and clinical effectiveness of central neurocytoma(CNC). Methods The clinical characteristics, imaging features, surgical methods, overall survival and progression-free survival of 13 patients with CNC treated surgically in the Department of Neurosurgery, Shenzhen Second People’s Hospital were analyzed retrospectively. The follow-up results were analyzed. Results A total of 11 gross total resection and 2 subtotal resection were performed, 10 were performed on the subdural cortical microscopic approach and 3 were performed on endoscopic endonasal surgery. After surgery, 2 cases of hydrocephalus occurred, 1 case improved spontaneously after conservative treatment and 1 case showed significant improvement after ventriculo-peritoneal shunting. After rehabilitation, 1 case of right-sided hemiplegia improved. There was 1 case of acute epidural haematoma that occurred 1 hour after surgery and was treated surgically. Postoperative radiotherapy was performed on 4 cases. Postoperative follow-up was from 9 to 93 months, with 1 case of recurrence. Conclusions Maximum safe resection is the primary treatment for CNC. Adjuvant radiotherapy is not recommended after complete resection. For patients with incomplete tumour resection, postoperative adjuvant radiotherapy may improve their prognosis.更多还原