【摘要】 病证结合、方证相应作为中医学理论体系的特色与精华，是中医辨证论治的基本方法，指导中医临床诊疗实践。但当前，以病证生物学基础、复方药效物质基础与作用机制为核心的“病-证-方”关键科学问题尚未完全阐明，围绕“病-证-方”研究的系统范式尚未建立，制约了中医学理论的创新与临床实践的发展。逍遥散出自宋代《太平惠民和剂局方》,具有疏肝解郁、养血健脾功效，主治肝郁血虚脾弱证，是方证相应治疗指导下治疗抑郁症肝郁脾虚证的经典方剂。基于病证结合、方证相应，聚焦逍遥散方证的科学内涵，从临床研究、基础研究、思路方法研究多维度探讨中医“病-证-方”研究范式，有助于揭示中医病证生物学基础，为西医学视域下中医“病-证-方”研究提供思路。更多还原

【Abstract】 As the defining characteristic and essence of traditional Chinese medicine(TCM), the integration of disease and syndrome, along with the correlation between syndrome and prescription, forms the foundation for syndrome differentiation and treatment, and guides the clinical diagnosis and treatment practice of TCM. However, key scientific questions remain unresolved regarding the "disease-syndrome-prescription" framework, particularly the biological basis of diseases and syndromes, the active pharmacodynamic constituents of compound formulas, and their mechanism of action. Furthermore, a systematic paradigm for investigating "disease-syndrome-prescription" relationships has not been established, restricting the innovation and development of TCM theory and practice. Xiaoyao Powder, which was first described in a medical book named Taiping Huimin Heji Ju Fang written during the Song Dynasty of China, disperses stagnated liver qi for relieving qi stagnation, thus nourishing the blood and strengthening the spleen, making it a representative prescription for addressing depression due to liver qi stagnation and spleen deficiency under the guidance of correspondence between syndrome and prescription. Therefore, base on the combination of disease and syndrome, and correspondence between syndrome and prescription, investigating the formula-syndrome scientific connotation of Xiaoyao Powder and exploring the research paradigm for the "disease-syndrome-prescription" can provide insights into TCM theory from the perspective of modern science.更多还原