【摘要】 目的 开发同时测定电子烟雾中三种新精神活性物质（5F-ADB、依托咪酯和替来他明）的超高效液相色谱-串联质谱（UPLC-MS/MS）分析方法，并系统研究了上述三种物质在穿戴材料上的沉积与脱附规律。方法 通过电子烟弹生成含目标物质的烟雾，将烟雾导入密闭空间，使其沉积在人造皮革、棉布和树脂镜片上。利用溶剂萃取结合UPLC-MS/MS检测不同脱附时间内上述材料中目标物质的残留量，分析脱附规律。结果 目标物质在人造皮革上残留时间最长，在树脂镜片上的残留时间最短，其脱附过程符合一级动力学模型。结论 分子脱附动力学模型的构建，为穿戴材料表面毒品残留的法医学鉴定及溯源分析提供了重要的方法学基础。更多还原

【Abstract】 Objective To develop a UPLC-MS/MS analysis method for the simultaneous determination of three novel psychoactive substances(5F-ADB, etomidate, and tiletamine) in e-cigarette aerosols, and to systematically study the deposition and desorption patterns of these substances on wearable materials. Methods Aerosols containing the target substances were generated using e-cigarette cartridges and introduced into a sealed chamber for deposition onto artificial leather, cotton fabric, and resin lenses. Solvent extraction combined with UPLC-MS/MS was used to detect the residual amounts of the target substances on the materials at different desorption times, and the desorption patterns were analyzed. Results The target substances exhibited the longest residual time on artificial leather, while their residual time was shortest on resin lenses. The desorption process followed a first-order kinetic model. Conclusion The construction of a molecular desorption kinetic model provides an important methodological foundation for the forensic identification and traceability analysis of drug residues on wearable material surfaces.更多还原