【摘要】 目的 探究活血通络方离子导入（HTRI）联合丁苯酞序贯疗法（BST对缺血性脑卒中（CIS）偏瘫患者的疗效和安全性。方法 回顾性选取安徽中医药大学附属滁州中西医结合医院2020年1月至2023年1月诊治的CIS偏瘫患者为研究对象。根据治疗方案将CIS偏瘫患者分为BST组（BST治疗）和联合组（BST联合HTRI治疗）。研究主要观察指标为治疗4周后的治疗总有效率和不良反应发生率；次要观察指标为治疗4周后脑动脉血流速度[大脑前动脉（ACA）、中动脉（MCA）及后动脉（PCA）]、神经功能[美国国立卫生研究院卒中量表（NIHSS）评分、中国卒中神经功能评分量表（CSS）评分]和肢体功能[Fugl-Meyer运动功能量表（FMA）评分、Barthel指数（BI）评分]。结果 研究共纳入患者87例，BST组43例、联合组44例。联合组总有效率显著高于BST组（P<0.05），且两组均未观察到不良反应发生。治疗前，两组脑动脉血流速度、神经功能和肢体功能差异无统计学意义（P>0.05）。治疗后，两组ACA、PCA、MCA血流速度以及FMA、BI评分均较治疗前显著上升（P<0.05），而NIHSS和CSS评分显著下降（P<0.05）。结论 与单独BST治疗相比，HTRI联合BST对CIS偏瘫患者疗效更显著，且并未增加不良反应发生率，安全性高。更多还原

【Abstract】 Objective To explore the efficacy and safety of the Huoxue Tongluo recipe iontophoresis(HTRI) combined with butylphthalide sequential therapy(BST) in patients with cerebral ischemic stroke(CIS) hemiplegia. Methods 87 patients with CIS hemiplegia treated in Chuzhou Chinese and Western Medicine Hospital affiliated to Anhui University of Chinese Medicine from January 2020 to January 2023 were retrospectively selected as study subjects,and were divided into the BST group(BST treatment) and the combination group(BST in combination with HTRI treatment) according to the treatment regimens. The main observation indicators were total treatment response rate and incidence of adverse reactions a?ter 4 weeks of treatment; the secondary observation indicators were cerebral artery flow velocity [anterior cerebral artery(ACA), middle cerebral artery(MCA) and posterior cerebral artery(PCA)],neurological function [National Institutes of Health Stroke Scale(NIHSS) score, Chinese Stroke Scale(CSS) score] and limb function [Fugl-Meyer Motor Function Scale(FMA) score, Barthel index(BI) score]. Results A total of 87 patients were included, including 43 patients in the BST group and 44 patients in the combination group. The total response rate in the combination group was significantly higher than that in the BST group(P<0.05), and no adverse reactions were observed in both groups. Before treatment, there were no significant differences in cerebral artery blood flow velocity, nerve function and limb function between the two groups(P>0.05).A?ter treatment, the flow velocity of ACA, PCA and MCA, and the scores of FMA and BI were significantly higher than those before treatment(P<0.05), while the scores of NIHSS and CSS decreased significantly(P<0.05). Conclusion Compared with BST therapy, HTRI combined with BST has a more significant effect in CIS patients with hemiplegia, with no increase in the incidence of adverse reactions, and has higher safety.更多还原