【摘要】 目的 探讨骨骼肌脂肪定量参数对T2DM患者IR的评估价值。方法 选取2018年1月至2021年1月于我院内分泌科住院治疗的T2DM患者150例（T2DM组），同期选取100名体检健康者为正常对照（NC）组。采用磁共振成像分析骨骼肌脂肪定量，包括肌间脂肪（IMAT）、肌筋膜下脂肪（SFAT）和皮下脂肪（SCAT）。受试者工作特征（ROC）曲线分析骨骼肌脂肪定量参数对T2DM合并IR的评估价值。结果 T2DM组IMAT、SFAT高于NC组[（10.05±1.34）%vs (7.16±2.06)%,(3.64±0.54)%vs (3.40±0.75)%,P<0.05],SCAT低于NC组[（20.16±6.34）%vs (24.97±6.57)%,P<0.05]。Pearson相关分析显示，IMAT、SFAT与HbA1c、胰岛素抵抗指数（HOMA?IR）呈正相关（P<0.05）,SCAT与HbA1c、HOMA?IR呈负相关（P<0.05）。ROC曲线分析显示，IMAT、SFAT、SCAT对IR评估价值的曲线下面积为0.716、0.667、0.736，敏感度为75.4%、72.9%、76.4%，特异度为71.4%、65.2%、68.1%。结论 骨骼肌脂肪定量参数与IR相关，对T2DM患者IR评估效能良好。更多还原

【Abstract】 Objective To explore the correlation between skeletal muscle fat content and insulin resistance(IR) in patients with type 2 diabetes mellitus(T2DM), and to evaluate the diagnostic value of skeletal muscle fat quantitative parameters for IR. Methods During January 2018 to January 2021, 150T2DM patients as observation group(T2DM group) and 100 healthy subjects as control group(NC group) were selected. All subjects underwent magnetic resonance imaging quantitatively analyzed skeletal muscle fat content,including intermuscular fat(IMAT),adipose tissue beneath fascia(SFAT) and subcutaneous fat(SCAT). Receiver operating characteristic(ROC) curve was used to analyze the diagnostic value of skeletal muscle fat quantitative parameters for IR in T2DM patients. Results The levels of IMAT and SFAT were higher in T2DM group than those in NC group [(10. 05±1. 34)% vs(7. 16±2. 06)%,(3. 64±0. 54)% vs(3. 40±0. 75)%, P<0. 05], while the level of SCAT was lower than in T2DM group than in NC group[(20. 16±6. 34)% vs(24. 97±6. 57)%,P<0. 05]. Pearson correlation analysis showed that IMAT and SFAT were positively correlated with HbA1c and HOMA?IR(P<0. 05), while SCAT was negatively correlated with HbA1c and HOMA?IR(P<0. 05). ROC curve analysis showed that the area under the curve of IMAT, SFAT, and SCAT for the diagnostic value of T2DM combined with IR were 0. 716, 0. 667 and 0. 736, with sensitivities of 75. 4%, 72. 9% and 76. 4%, and specificity of 71. 4%,65. 2%and 68. 1%. Conclusion Skeletal muscle fat contentis associated with IR. The quantitative parameters of skeletal muscle fat have good diagnostic efficacy for T2DM complicated with IR.更多还原