【摘要】 目的 分析1型糖尿病（type 1 diabetes mellitus, T1DM）儿童青少年血清25-羟维生素D₃[(25-（OH）D₃]水平，探讨其与糖化血红蛋白（HbA1c）水平的关系。方法 收集2016年1月—2021年12月就诊于青岛大学附属医院儿童内分泌消化科的T1DM儿童青少年129例，设为T1DM组；根据HbA1c水平将T1DM组分为两亚组：血糖控制良好组（A组，HbA1c<7.5%）和血糖控制不良组（B组，HbA1c≥7.5%）。收集健康儿童青少年33例，设为对照组。收集所有入组儿童青少年的一般临床资料，检测其血清钙、磷、25-（OH）D₃、HbA1c水平。结果T1DM组儿童青少年BMI及血清钙、磷和25-（OH）D₃水平显著低于对照组（t=-15.665～-3.679,P<0.05）,A组血清25-（OH）D₃水平明显高于B组（t=3.857,P<0.05）,二元logistic回归分析显示，25-（OH）D₃水平降低是T1DM儿童青少年血糖控制不良的危险因素（OR=1.141,95%CI=1.051～1.239,P<0.05）。结论 T1DM儿童青少年血清25-（OH）D₃水平低于健康青少年，且血糖控制不佳可能与血清25-（OH）D₃水平降低有关；T1DM儿童青少年应该适当补充维生素D,并加强其血糖管理。更多还原

【Abstract】 Objective To investigate the serum levels of 25-hydroxyvitamin D₃ [25-（OH）D₃] in children and adolescents with type 1 diabetes mellitus（T1DM）, and to investigate the relationship between 25-（OH）D₃ levels and glycosylated hemoglobin（HbA1c） levels. Methods We included 129 children and adolescents with T1DM who visited the Department of Pediatric Endocrinology, Metabolism & Gastroenterology of The Affiliated Hospital of Qingdao University from January 2016 to December 2021（T1DM group）. They were divided into two subgroups according to HbA1c levels: patients with good glycemic control（group A, HbA1c<7.5%） and those with poor glycemic control（group B, HbA1c≥7.5%）. Thirty-three healthy children and adolescents were selected as control group. The general data and serum calcium, phosphorus, 25-（OH）D₃, and HbA1c levels of the subjects were collected. Results The T1DM group showed a significantly lower body mass index and significantly lower serum calcium, phosphorus, and 25-（OH）D₃ levels than the control group（t=-15.665--3.679,P<0.05）. The 25-（OH）D₃ level in group A was significantly higher than that in group B（t=3.857,P<0.05）. The binary logistic regression analysis showed that decreased 25-（OH）D₃ levels were a risk factor for poor blood sugar control in children and adolescents with T1DM（OR=1.141,95%CI=1.051-1.239,P<0.05）. Conclusion Children and adolescents with T1DM have decreased 25-（OH）D₃ levels compared with healthy children and adolescents, and the decrease may be closely related to poor blood glucose control. It is necessary for children and adolescents with T1DM to supplement vitamin D and strengthen blood glucose management.更多还原