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性激素在绝经激素治疗中的应用及展望

Application and prospects of sex hormones in menopausal hormone therapy

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【作者】 马菱蔚冯源原孙鑫萌吴志勇张炜夏和霞

【Author】 MA Lingwei;FENG Yuanyuan;SUN Xinmeng;WU Zhiyong;ZHANG Wei;XIA Hexia;Department of Gynecology,Obstetrics and Gynecology Hospital of Fudan University;Department of Reproductive Endocrinology,Obstetrics and Gynecology Hospital of Fudan University,Shanghai Key Laboratory of Female Reproductive Endocrine Related Disease;

【通讯作者】 夏和霞;

【机构】 复旦大学附属妇产科医院妇科上海市女性生殖内分泌相关疾病重点实验室

【摘要】 随着女性卵巢功能的衰退,全身其他重要器官功能也逐步下降,部分围绝经期女性出现躯体、精神症状或疾病,影响女性生活质量。绝经激素治疗(menopause hormone therapy,MHT)通过添加外源性性激素,改善并缓解卵巢功能下降甚至衰竭所导致的相关症状。该文就孕激素、雌激素以及雌孕激素复方制剂等各类性激素在MHT中的应用范围、常用方案及风险获益进行探讨、总结,以期对围绝经期女性用药提供参考。

【Abstract】 With the failure of ovarian function, the function of other important organs is also gradually decreased. Some perimenopausal women experience physical, mental symptoms or illnesses, which affect their quality of life. Menopausal hormone therapy(MHT) improves and alleviates the symptoms caused by decline or even failure of ovarian function by adding exogenous sex hormones. This paper reviewed the application scope, commonly regimens and the risks and benefits of various sex hormones, including progestogens, estrogens, combined estrogen-progestogens preparations in MHT, in order to provide a reference for drug use in perimenopausal women.

  • 【文献出处】 世界临床药物 ,World Clinical Drug , 编辑部邮箱 ,2024年02期
  • 【分类号】R711.75
  • 【下载频次】34
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