【摘要】 目的 调查分析海南省献血人群HTLV流行状况，为科学制定本地区血液安全筛查策略提供参考依据。方法 采用酶联免疫吸附试验(ELISA)对献血者标本进行抗-HTLV筛查，结果为反应性者进行免疫印迹法(WB)确证。结果 海南省2016—2023年共检测献血者标本326 269份，抗-HTLV初筛有反应性标本117份，初筛阳性率为0.036%(117/326 269),免疫印迹法(WB)确证结果为阳性9份，确认阳性率为0.0027%(9/32 6269)。抗-HTLV阳性率在不同人口学特征人群中存在分布差异，男性显著高于女性(P<0.05)。结论 海南省献血者人群中存在抗-HTLV阳性献血者，虽属于HTLV低流行区，但为了血液安全，应继续加大血液筛查人群范围和阳性献血者的流调。更多还原

【Abstract】 Objective To investigate the prevalence of human T-lymphotropic virus(HTLV) infection among voluntary blood donors and provide reference for the development of blood safety screening strategy in Hainan Province. Methods Enzyme linked immunosorbent assay(ELISA) was used to screen for HTLV, and the reactive samples were confirmed by Western blot(WB). Results A total of 326 269 blood samples from 2016 to 2023 in Hainan were screened, among which 117 samples showed reactive results for initial screening, with a reactive rate of 0.036%(117/326 269), and 9 were confirmed positive by WB, with a positive rate of 0.002 7%(9/326 269). The prevalence of HTLV antibody varied among different demographic groups, with a significantly higher rate among males compared to females(P<0.05). Conclusion There are HTLV antibody positive blood donors in the voluntary blood donors in Hainan. Although it is a low prevalence area for HTLV, it is necessary to continue to expand the blood screening and conduct epidemiological investigations on positive blood donors for blood safety.更多还原