【摘要】 目的 分析11年来海南地区无偿献血人群核酸检测(NAT)结果、评估HBV、HCV和HIV的NAT检测后残余风险。方法 收集本中心2012年1月—2022年12月的无偿献血者NAT检测结果数据，利用新发感染率-窗口期残余风险模型对献血者进行HBV、HCV和HIV窗口期残余风险评估。结果 2012年1月—2022年12月，海南地区无偿献血者捐献的血液中，来自初次献血者的占比45.02%(522 684/1 161 042)、重复献血者(含固定献血者)占54.98%(638 358/1 161 042),固定献血者占30.48%(354 227/1 162 042);NAT总阳性率为0.19%(2 151/1 161 042);NAT检测后HBV窗口期残余风险为62.54/百万，HCV残余风险为0.431/百万，HIV残余风险为0.791/百万。结论 海南地区无偿献血者开展NAT检测明显降低HCV残余风险，输血传播HBV、HCV、HIV的窗口期残余风险处于较低的水平。更多还原

【Abstract】 Objective To analyze the nucleic acid testing(NAT) results of voluntary blood donors in Hainan and evaluate the residual risk in the window period of NAT for hepatitis B virus(HBV), hepatitis C virus(HCV) and human immunodeficiency virus(HIV). Methods A retrospective analysis on the NAT results of voluntary blood donors at our center from January 2012 to December 2022 was conducted.The new infection rate-window period residual risk model was used to assess the residual risk of HBV, HCV and HIV among blood donors. Results From January 2012 to December 2022, among the blood donated by voluntary blood donors in Hainan, 45.02%(522 684/1 161 042) were collected from first-time donors, 54.98%(638 358/1 161 042) were from repeat donors(including regular donors), and 30.48%(354 227/1 162 042) were from regular donors. The total reactive rate of NAT was 0.19%(2 151/1 161 042). After NAT, the residual risk in the window period of HBV, HCV and HIV was 62.54 per million, 0.431 per million and 0.791 per million, respectively. Conclusion The implementation of NAT among voluntary blood donors in Hainan significantly reduces the residual risk of HCV, and the residual risk of HBV, HCV and HIV transmission in the window period is at a relatively low level.更多还原