【摘要】 目的 分析1990—2019年消化性溃疡（PUD）的疾病负担水平和变化趋势。方法 通过GBD2019数据库获得PUD自1990至2019年间的相关数据，计算其对应的年龄标准化率、年百分比变化、平均年度百分比变化，采用Excel和R软件进行分析。结果 2019年全球PUD标化患病率为99.4/10万[95%CI（83.9,117.5）]，较1990年的143.4/10万[95%CI（120.5,170.2）]下降。2019年标化伤残调整寿命年（DALYs）率为74.4[95%CI（69.0,81.9）],1990至2019年估计年百分比变化（EAPC）结果为-3.47%[95%CI（-3.58，-3.37）]，显示标化DALYs率呈下降趋势。PUD的患病率、DALYs率均随着年龄的增加而增加，同年龄段男性标化DALYs率多高于女性。社会人口指数与PUD的标化患病率(R=-0.45,P<2.2e^-16)、标化DALYs率(R=-0.79,P<2.2e^-16)之间存在负相关关系。结论 1990—2019年全球PUD疾病负担下降，但在经济发展水平较好的国家PUD疾病负担下降出现减缓或暂停趋势。更多还原

【Abstract】 Objective To estimate the level and evolving pattern of peptic ulcer disease（PUD） burden from 1990to 2019.Methods The related data of PUD from 1990 to 2019 were obtained from GBD 2019 database.The corresponding age-standardized rate,annual percentage change,average annual percentage change were calculated and analyzed by Excel and R software.Results The global standardized prevalence of PUD was 99.4/100 000（95%CI 83.9 to117.5） in 2019,and decreased from 143.4/100 000（95%CI 120.5 to 170.2） in 1990.The standardized disability-adjusted disease years（DALYs） rate was 74.4（95%CI 69.0 to 81.9） in 2019.The estimated annual percentage change（EAPC） from1990 to 2019 was-3.47%（95%CI-3.58 to-3.37）,indicating that the standardized DALYs rate was declining.The prevalence and DALYs of PUD increased with age.The standardized DALYs rate was higher in males than in females in the same age group.Sociodemographic index（SDI） was negatively correlated with the standardized prevalence of PUD(R=-0.45,P<2.2e^-16) and the standardized DALYs rate(R=-0.79,P<2.2e^-16).Conclusion The worldwide burden of PUD declined from 1990 to 2019,but the decline had begun to slow or pause in countries with better economic development levels.更多还原