【摘要】 维生素D作为一种脂溶性维生素，在调节骨代谢及钙离子方面深受国内外学者重视。但随着近些年多项系统评价和大量的观察性研究显示，维生素D缺乏与感染性疾病发病及发展存在密切相关性，具有活性的维生素D通过维生素D结合蛋白与相应受体可触发一系列免疫反应，包括对抗菌肽、单核细胞/巨噬细胞、T细胞与B细胞等的激活引起相关信号通路达到抗感染的作用。本文通过对维生素D受体（VDR）-抗菌肽轴、先天性免疫、适应性免疫等几方面对其抗感染机制进行阐述，同时对其相关病毒性感染性及细菌性感染等疾病进行综述。旨在探讨维生素D水平与感染性疾病的研究现状，虽然目前大量研究证实维生素D与感染性疾病存在相应联系，但仍缺乏其他感染性疾病充实相关数据。更多还原

【Abstract】 As a fat-soluble vitamin, vitamin D has been deeply valued by scholars at home and abroad in regulating bone metabolism and calcium ions, but with a number of systematic reviews and a large number of observational studies in recent years, vitamin D deficiency is closely related to the onset and development of infectious diseases, and active vitamin D can trigger a series of immune responses through vitamin D-binding proteins and corresponding receptors, including the activation of antibacterial peptides, monocytes/macrophages, T cells and B cells to cause related signaling pathways to achieve anti-infection. In this paper, the anti-infection mechanism of vitamin D receptors(VDR)-antimicrobial peptide axis, innate immunity and adaptive immunity is elaborated, and its related viral infectious and bacterial infections are reviewed. To explore the current status of research on vitamin D levels and infectious diseases, although a large number of studies have confirmed the corresponding association between vitamin D and infectious diseases, there is still a lack of data on other infectious diseases.更多还原