【摘要】 目的 探索在计算机辅助显微镜下评估Ki-67指数的方法以提高医生间的一致性。方法 医生用显微镜下平均值法和计算机辅助显微镜下多视野评估100例浸润性乳腺癌的Ki-67指数，计算ICC分析一致性。结果 显微镜下3位医生的ICC为0.836;计算机辅助下3位医生评估视野数为1、3、5、7时ICC分别为0.743、0.878、0.917和0.934,一致性随视野数增加而递增。在同、异质性，组织学分级等不同分类中，当视野数≥5时，计算机辅助下医生对Ki-67指数评估的一致性均高于显微镜下医生间的一致性。结论 计算机辅助显微镜评估Ki-67指数的方法能提高医生间的一致性。该方法临床可操作性强，有望早日应用于病理医生常规工作中。更多还原

【Abstract】 Objective To propose a method of computer-aided assessment for Ki-67 index to improve inter-physician consistency. Methods A total of 100 cases of invasive breast cancer were evaluated by two methods: the average method under microscope and multi-field assessment for computer-aided. Intraclass correlation coefficient(ICC) was calculated for analysis consistency. Results The ICC of three doctors was 0.836. The ICC of the doctors with computer-aided were 0.743, 0.878, 0.917 and 0.934 at 1, 3, 5 and 7 fields, respectively. It showed that the more fields, the better consistency. For different classification, including homogeneity or heterogeneity, histological grade and so on, when the number of assessed fields ≥ 5, the consistency of the computer-aided doctors was higher than that of doctors under the microscope. Conclusion The method of computer-aided assessment for Ki-67 index can improve the consistency among doctors. The method has strongly clinical operability and is expected to be applied in the routine work of pathologists as soon as possible.更多还原