【摘要】 心血管疾病（cardiovascular disease, CVD）是危害全球的重大疾病之一，其发病率和死亡率逐年上升，给国家带来沉重的经济及社会负担。神经氨酸酶（neuraminidase, NEU）是一类可以水解细胞表面唾液酸的酶家族，其中神经氨酸酶1(neuraminidase 1,NEU1)参与体内多种代谢途径及信号的调节，在CVD的发生发展中起到了重要作用。综述NEU1在多种心血管疾病中的研究进展，包括其作用机制等方面，并总结了目前NEU1相关抑制剂的研究现状，以期未来能够为NEU1在心血管疾病的研究提供依据和方向。更多还原

【Abstract】 Cardiovascular disease(CVD) is one of the major global health threats, with increasing morbidity and mortality rates, posing a heavy economic and social burden in China. Neuraminidases(NEU) are a class of enzymes that hydrolyze cell surface sialic acid. Among them, neuraminidase-1(NEU1) plays an important role in the regulation of various metabolic and signaling pathways in the progression of CVD. This article provides an overview of the progress of NEU1 research in a variety of cardiovascular diseases, including its mechanisms of action. It also summarizes the current research status of NEU1 inhibitors, aiming to provide a basis and direction for future research on NEU1in CVD.更多还原