【摘要】 葫芦素具有四环素葫芦烷核骨架并且高度氧化，现代药理研究表明其具有抗肿瘤、保肝、抗炎、提高机体免疫等多种生物活性，其中葫芦素B、葫芦素D、葫芦素E、葫芦素I、雪胆甲素、雪胆乙素有抗肿瘤活性，对肝癌、乳腺癌、前列腺癌、肺癌及其他肿瘤细胞均有诱导凋亡、抑制增殖的药理作用；能够通过调节信号转导及转录活化因子3(STAT3)、丝裂原活化蛋白激酶（MAPK）和其他信号通路、阻滞细胞周期、影响细胞骨架等，发挥抗肿瘤作用，对部分恶性肿瘤的治疗药物开发具有深远意义。更多还原

【Abstract】 Cucurbitin has tetracycline cucurbitane nuclear skeleton and is highly oxidized. Modern pharmacological studies have shown that it has various biological activities such as anti-tumor, liver protection, anti-inflammatory, and improving the body’s immunity, among which cucurbitin B, cucurbitin D, cucurbitin E, cucurbitin I, hemslecin A and 23,24-dihydrocucurbitacin F have anti-tumor activities. It can induce apoptosis and inhibit proliferation of liver cancer, breast cancer, prostate cancer, lung cancer and other tumor cells. By regulating signal transduction and transcriptional activation factor 3(STAT3), mitogen activated protein kinase(MAPK) and other signaling pathways, blocking cell cycle and affecting cytoskeleton, it can play an anti-tumor role, which has farreaching significance for the development of therapeutic drugs for some malignant tumors.更多还原