【摘要】 鼻黏膜作为呼吸系统与体外环境接触的第一道防线,在疾病预防与治疗中发挥着举足轻重的作用。然而传统的体外模型存在多种限制,难以满足现代医学研究的迫切需求,随着生物医学技术的快速发展,鼻黏膜类器官及鼻黏膜器官芯片的构建能够提供更准确、可靠的模型,用以研究鼻黏膜相关疾病的病理过程和发生机制。该文较系统地综述了鼻黏膜类器官及鼻黏膜器官芯片在生理模型构建、疾病建模、药物筛选以及临床应用等多个领域取得的研究进展,以期望为鼻黏膜类器官及器官芯片的发展与应用提供一定的参考。更多还原

【Abstract】 The nasal mucosa, as the first line of defense in contact with the external environment for the respiratory system, plays a crucial role in disease prevention and treatment. However, traditional in vitro models have various limitations and fail to meet the urgent demands of modern medical research. With the rapid development of biomedical technology, the construction of nasal organoids and nose-on-a-chip provides more accurate and reliable models for studying the pathological processes and pathogenesis of nasal-related diseases. This article provides a comprehensive review of the research progress achieved in the areas of physiological model construction, disease modeling, drug screening, and clinical applications of nasal organoids and nose-on-a-chip, hoping to provide a reference for the development and application of nasal organoids and nose-on-a-chip.更多还原