【摘要】 目的 在健康信念模式指导下探讨腹膜透析（PD）患者促红细胞生成素（EPO）注射依从性现状及相关影响因素。方法 纳入2021年1月至6月在中山大学附属第一医院规律随访并注射EPO的PD患者244例。将EPO不依从定义为使用少于90%的处方剂量或报告漏注射的情况。根据依从性情况分为依从组与不依从组，比较组间差异，并用logistic回归分析EPO治疗不依从的影响因素。结果 患者年龄（47.1±12.4）岁，男性占46.7%，中位透析月33.3(11.6,73.9)个月。EPO不依从率为59.8%，血红蛋白达标率为63.5%。多因素logistic分析发现短透析月、注射疼痛、低药物效力满意度（P<0.05）是EPO不依从的危险因素。结论 PD患者EPO治疗存在达标率低、依从性差的现象。短透析月、注射疼痛、低药物效力满意度是EPO不依从的危险因素。更多还原

【Abstract】 Objective To analyze the current situation of subcutaneous erythropoietin(EPO)compliance and associated risk factors in patients with peritoneal dialysis(PD)by using the Health Belief Model. Methods A total of 244 PD patients who were treated with EPO and regularly followed up in the First Affiliated Hospital of Sun Yat-sen University from January to June 2021 were recruited. Noncompliance was defined as less than 90% use of the prescribed dose or missed injections on the questionnaire. Patients were divided into compliance and non-compliance group and the differences between the two groups were compared. Multivariate logistic regression was used to identify risk factors of non-compliance of EPO. Results The mean age of the enrolled patients was(47.1±12.4)years,46.7% were male,and the median vintage of PD was 33.3(11.6,73.9)months. The rate of non-compliance to EPO was 59.8% and 63.5% of the patients reached the targeted hemoglobin level. Multivariate Logistic regression analysis showed that shorter PD vintage,injection pain,low satisfaction with EPO efficacy were risk factors of non-compliance of EPO(all P<0.05). Conclusion PD patients with EPO treatment in our center have low targeted hemoglobin level and compliance rate. Shorter PD vintage,injection pain,lower satisfaction with efficacy are risk factors for the non-compliance to EPO.更多还原