【摘要】 系统性红斑狼疮(SLE)是一种累及多个器官和系统的慢性自身免疫性疾病。近年来，发现微小RNA(miRNA)参与基因表达的生理调控，在自身免疫性疾病的发病机制中发挥重要作用。研究表明，miRNA与SLE发病和自身免疫功能紊乱有关，miRNA可能通过Ⅰ型干扰素通路、DNA低甲基化、辅助性T细胞/调节性T细胞的功能异常、DC持续活化、炎性因子等方式参与SLE发病。现对miRNA与SLE发病之间的关系和作用机制研究进展进行综述。更多还原

【Abstract】 Systemic lupus erythematosus is a chronic autoimmune disease involving multiple organs and systems. In recent years, it has been found that miRNA is involved in the physiological regulation of gene expression and plays an important role in the pathogenesis of autoimmune diseases.Studies have shown that miRNA is related to the pathogenesis of SLE and autoimmune dysfunction.miRNA may be involved in the pathogenesis of SLE through type I interferon pathway, DNA hypomethylation, dysfunction of helper T cells/regulatory T cells, continuous activation of DC,and inflammatory factors.In this paper, the relationship and mechanism between miRNA and SLE and the research progress of the effect of traditional Chinese medicine are reviewed.更多还原