【摘要】 目的 研究非肌层浸润性膀胱肿瘤二次电切对检测残余肿瘤和肿瘤复发的影响。方法 收集2010年1月至2023年1月在北京大学人民医院泌尿外科进行二次电切的114例膀胱癌患者的基本信息、手术及术后相关信息,二次电切术后患者中位随访时间18.47个月。根据二次电切病理是否阳性及二次电切术后随访是否复发各自分为两组,即肿瘤残余组与无肿瘤残余组,以及肿瘤复发组与无肿瘤复发组。探讨了影响首次电切术后肿瘤残余以及二次电切术后肿瘤复发的相关因素。结果 肿瘤残余组与无肿瘤残余组相比,两组患者性别、年龄、肿瘤单灶/多灶、首次电切病理分级、二次电切距离首次电切间隔时间差异均无统计学意义(均P>0.05)。二次电切后随访期间肿瘤复发组与无肿瘤复发组相比,患者性别、肿瘤单灶/多灶、首次电切病理分级均无统计学差异,但是两组患者年龄差异有统计学意义(P=0.008),Logistic多因素回归分析结果显示年龄是二次电切术后肿瘤复发的危险因素(P=0.044)。结论 患者性别、肿瘤单灶/多灶、首次电切病理分级、二次电切距离首次电切间隔时间与首次电切术后肿瘤是否残余,以及二次电切后随访期间肿瘤有无复发均无关,而患者年龄是二次电切术后肿瘤复发的危险因素。更多还原

【Abstract】 Objective To analyze the impact of second transurethral resection of bladder tumor(second TURBT) in detecting residual tumor and tumor recurrence.Methods The basic information,surgical and postoperative information of 114 patients with bladder cancer who underwent second TURBT in the Department of Urology,Peking University People’s Hospital from January 2010 to January 2023were collected,and the median follow-up time was 18.47 months.According to whether the pathology of second TURBT is positive and whether it recurs after second TURBT,they are divided into two groups,namely tumor residual group and no tumor residual group,and tumor recurrence group and no tumor recurrence group.The factors affecting tumor residue at the first transurethral resection and tumor recurrence after second TURBT were explored.Results The no tumor residual group and the tumor residual group did not differ significantly in terms of gender,age,tumor monofocal/multifocal tumor,pathological grade of first precedure,or time to second TURBT(all P>0.05).The tumor recurrence group after second TURBT did not differ significantly from the group without tumor recurrence in terms of gender,first transurethral resection completion,tumor monofocal/multifocal,or pathological grade,but there was a statistically significant difference between the two groups in terms of age(P=0.008),and logistic multivariate regression analysis showed that age was a risk factor for tumor recurrence after resection(P=0.044).Conclusion The age of the patient is related to tumor recurrence after the second TURBT,while the gender,monofocal/multifocal tumor,pathological grade of first transurethral resection,and second TURBT time to first transurethral resection are not related to whether the tumor remains at the first transurethral resection and whether the tumor recurs after the second TURBT.更多还原