【摘要】 目的 研究分析静脉应用大剂量氨甲环酸降低椎间孔镜患者围手术期出血风险。方法 回顾性分析2015年1月—2018年12月福建省龙岩市第二医院收治的椎间孔镜手术患者100例的临床资料，根据治疗方法不同划分成两组，即治疗组与对照组，治疗组50例患者静脉应用大剂量氨甲环酸，对照组50例患者静脉应用氯化钠，观察记录两组患者手术中出血量、住院时间、凝血酶原时间、术野质量评分（SSFQ）、最大血红蛋白丢失量、血红蛋白、尿素氮、肌酐、纤维蛋白原等指标，并进行对比分析。结果 治疗组患者术中出血量（13.42±6.09）mL、住院时间（1.91±0.23）d、最大血红蛋白丢失量（22.98±4.23）mL、凝血酶原时间（12.87±1.10）s、SSFQ评分（2.01±0.45）分均低于对照组的（29.01±12.31）mL、（3.08±0.43）d、（41.34±4.53）mL、（13.81±1.11）s、（3.08±0.23）分，差异有统计学意义（t=8.026、16.966、20.951、4.253、14.965,P<0.05）。结论 在椎间孔镜患者围手术期静脉应用大剂量氨甲环酸，可降低围手术期出血的发生率，有利于手术安全且顺利地实施，对于促进患者尽早康复具有显著的意义。更多还原

【Abstract】 Objective To study and analyze the intravenous application of high-dose tranexamic acid to reduce the risk of perioperative bleeding in patients undergoing intervertebral foraminoscopy.Methods Retrospective analysis of clinical data of 100 patients undergoing intervertebral foraminoscopy at Longyan Second Hospital from January 2015to December 2018 were conducted, and they were divided into two groups according to different treatment methods,namely the treatment group and the control group. High-dose tranexamic acid was applied intravenously in 50 patients in the treatment group and sodium chloride was applied intravenously in 50 patients in the control group. The intraoperative bleeding, hospital stay, prothrombin time, Scores of Surgical Field Quality(SSFQ), maximum hemoglobin loss, hemoglobin, urea nitrogen, creatinine, fibrinogen and other indexes were observed and recorded in the two groups, and were compared and analyzed.Results Intraoperative bleeding(13.42±6.09) mL, hospital stay(1.91±0.23)d, maximum hemoglobin loss(22.98±4.23) mL, prothrombin time(12.87±1.10) s and SSFQ score(2.01±0.45) points of patients in the treatment group were lower than those in the control group(29.01±12.31) mL,(3.08±0.43) d,(41.34±4.53) mL,(13.81±1.11) s,(3.08±0.23) points, the difference was statistically significant(t=8.026, 16.966, 20.951,4.253, 14.965, P<0.05).Conclusion Intravenous application of high-dose tranexamic acid during the perioperative period in patients undergoing intervertebral foraminoscopy can reduce the occurrence of perioperative bleeding, facilitate the safe and smooth performance of surgery, and have significant significance in promoting the early recovery of patients.更多还原