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右归丸治疗骨质疏松症作用机制的研究进展

Research Progress on the Mechanism of Yougui Pill(右归丸) in the Treatment of Osteoporosis

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【作者】 李婷; 孙丰雷; 李念虎;

【Author】 LI Ting;SUN Fenglei;LI Nianhu;The First Clinical Medical College of Shandong University of Traditional Chinese Medicine;Affiliated Hospital of Shandong University of Traditional Chinese Medicine;

【通讯作者】 孙丰雷;

【机构】 山东中医药大学第一临床医学院; 山东中医药大学附属医院;

【摘要】 右归丸治疗骨质疏松症的作用机制主要为促进骨髓间充质干细胞(BMSCs)成骨分化、抑制BMSCs向脂肪细胞分化进而促进成骨细胞分化、增殖,以及通过调控AMPK/mTOR、Wnt/β-catenin等信号通路,下丘脑-垂体-肾上腺轴和神经肽网络来调节骨代谢,从而防治骨质疏松症。

【Abstract】 The mechanism of Yougui Pill in the prevention and treatment of osteoporosis is mainly to promote the osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs) and inhibit the differentiation of BMSCs into adipocytes. Furthermore, it can promote osteoblast differentiation and proliferation, and regulate AMPK/mTOR, Wnt/β-catenin and other signaling pathways, hypothalamic-pituitary-adrenal axis and neuropeptide network to regulate bone metabolism and prevent and treat osteoporosis.

【基金】 山东省自然科学基金面上项目(ZR2019MH044);山东省老年医学学会重点项目(LKJGG2021Z009)
  • 【文献出处】 中医药导报 ,Guiding Journal of Traditional Chinese Medicine and Pharmacy , 编辑部邮箱 ,2023年01期
  • 【分类号】R285
  • 【下载频次】109
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