【摘要】 目的 为研究安徽省金黄色葡萄球菌的流行病学特征，收集了安徽某三级医院100株临床金黄色葡萄球菌，以期为预防和治疗金黄色葡萄球菌感染提供理论依据。方法 2021年9月—12月期间，收集来自安徽某三级医院不同患者临床产生的100株金黄色葡萄球菌分离株，通过Vitek2 Compact System 3鉴定分离株，并用多位点序列分型(MLST)进行分子分型。结果 本研究对100株金黄色葡萄球菌分离株做了17种抗生素的药敏实验，结果显示对青霉素的耐药率最高，高达93%。统计学分析法证明大部分对耐甲氧西林金黄色葡萄球菌(MRSA)比甲氧西林敏感金黄色葡萄球菌(MSSA)的耐药率高；并发现28个ST型，ST59、ST6697分型数量分布最多，CC5检出率均高于其他克隆群。结论 安徽某三级医院的金黄色葡萄球菌分离株具有独特的分子特征和抗生素耐药性特征，抗生素耐药性特征可能与当地抗生素使用趋势有关。更多还原

【Abstract】 Objective To develop a theoretical framework for the prevention and treatment of S. aureus, 100clinical S. aureus isolates from the tertiary care hospital in Anhui were gathered to examine the epidemiological characteristics of the disease in Anhui Province. Methods 100 clinical S. aureus isolates from patients in tertiary care hospital in Anhui were gathered between September 2021 and November 2021. By using the VITEK2 Compact System 3, the isolates were recognized, and their genotypes were molecularly typed using multi-locus sequence typing(MLST). Results In this study, 17 antibiotic sensitivity tests were done on 100 S. aureus isolates, of which the highest resistance rate to penicillin was 93%. Statistical analysis was used to prove that most MRSA had a higher resistance rate than MSSA; and 28 ST types were found, with the largest distribution of ST59 and ST6697 typing numbers, and all CC5 detection rates were higher than other clonal groups. Conclusion Staphylococcus aureus isolates from a tertiary care hospital in Anhui have unique molecular and antibiotic resistance characteristics, and the antibiotic resistance characteristics may be related to local antibiotic use trends.更多还原