【摘要】 肝脏对纳米粒子的非特异性清除严重阻碍了纳米药物的临床转化。由于实验手段的限制，通过数学模型探究纳米粒子在肝窦内的运动特性对其肝脏清除的影响，具有重要应用价值。本研究利用基于有限元法(FEM)的欧拉-拉格朗日方法模拟了纳米粒子在仿生小鼠肝窦中的运动。结果表明，颗粒尺寸和肝窦的弯曲程度能够通过改变纳米粒子与窦内细胞的碰撞频率而影响其肝脏清除率；而颗粒密度对粒子运动特性及其肝脏清除率无显著影响。本研究从纳米粒子的运动特性角度出发，为面对肝脏清除的纳米载体的设计提供了理论指导，进而推进其临床转化进程。更多还原

【Abstract】 Non-specific clearance of nanoparticles by liver severely hinders clinical translation of nanomedicines. Due to the limitation of experimental tools, mathematical models show great application in investigating nanoparticles motion effects in liver sinusoids on their liver clearance. Based on the finite element method(FEM), the Euler-Lagrange method was used to simulate nanoparticle motion in mimic murine liver sinusoid(MLS) models. The results show that particle size and tortuosity of liver sinusoids affect liver nanoparticles clearance by changing their collision frequency with liver sinusoidal cells. Meanwhile, particle density had no significant effect on nanoparticle motion and its liver clearance. This study provides theoretical guidance for the design of nanocarriers for possible liver clearance from the perspective of nanoparticle motion characteristics, which may help for clinical translation.更多还原