【摘要】 目的：探讨老年2型糖尿病患者使用消渴丸进行降糖治疗的效果以及在老年2型糖尿病患者中25-（OH）D₃、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）与糖尿病肾病之间的相关性。方法：将164例患者按照研究需要先后进行2次分组。分组一：未使用消渴丸降糖治疗的为对照组，共101例，使用消渴丸治疗者为观察组，共63例。分组二：将164例患者有无糖尿病肾病分为2组，单纯糖尿病组和糖尿病肾病组，每组82例。结果：分组一结果：两组HbA1c、FBG差异有统计学意义（P<0.05）。分组二结果：NLR、PLR、25-（OH）D₃是影响患者肾功能的危险因素。使用25-（OH）D₃、NLR指标检查有助于早期发现并防治糖尿病肾病；其中25-（OH）D₃的检测敏感度高达97.6%。结论：在老年2型糖尿病患者中，使用消渴丸进行降糖治疗比单一使用西药治疗更易接受且降糖效果更佳。在老年2型糖尿病患者中，进行25-（OH）D₃、NLR、PLR的检测，能更好筛查和及时发现老年糖尿病患者的糖尿病肾病。更多还原

【Abstract】 Objective: To investigate the hypoglycemic effect of Xiaoke Pills in elderly type 2 diabetes patients and the correlation between 25-（OH）D₃, NLR, PLR and DN in elderly type 2 diabetes patients. Methods: A total of 164 patients were divided into two groups according to the study requirements. Group 1: There were 101 cases in the control group who did not use Xiaoke Pills for hypoglycemic treatment, and 63 cases in the observation group who used Xiaoke Pills for hypoglycemic treatment.Group 2: A total of 164 patients were divided into two groups according to whether they had diabetic nephropathy, namely simple diabetic group and diabetic nephropathy group, with 82 cases in each group. Results: Group 1: There were statistically significant differences in HbA1c and FBG between the two groups（P<0.05）. Group 2: NLR, PLR and 25-（OH）D₃ were risk factors for renal function. The use of 25-（OH）D₃ and NLR indicators were helpful for early detection and prevention of diabetic nephropathy.The sensitivity of 25-（OH）D₃ was 97.6%. Conclusions: In elderly patients with type 2 diabetes mellitus, the use of Xiaoke Pills for hypoglycemic treatment is more acceptable and has better hypoglycemic effect than the single use of western medicine.In elderly patients with type 2 diabetes, the detection of 25-（OH）D₃, NLR and PLR can better screen and timely discover diabetic nephropathy in the elderly.更多还原