【摘要】 目的 探索酒精不同摄入量对丙型肝炎病毒（HCV）感染患者的肝功能和肝纤维化的影响。方法 选取近1年来新洲区人民医院收治的HCV感染患者，且病程在10年以上，根据日酒精摄入量分为轻度酒精摄入（20～50 g/d）组和重度酒精摄入（>50 g/d）组，然后检测患者肝功能和肝纤维化指标。结果 轻度酒精摄入组的AST为（115.12±12.14）U/L,ALT (121.83±11.21)U/L，总胆红素（TBil）(84.95±6.21)μmol/L,γ-谷氨酰转肽酶（γ-GT）(72.31±9.21)U/L，均显著低于重度酒精摄入组患者AST (141.34±12.91)U/L,ALT (145.57±10.23)U/L,TBil(95.43±5.38)μmol/L,γ-GT (85.48±8.24)U/L，均P<0.05）；同时，轻度酒精摄入组肝纤维化指标层粘连蛋白（LN）(162.38±21.34)mg/L,III型前胶原（PC-III）(146.74±23.43)μg/L,IV型胶原（IV-C）(198.57±30.34)μg/L，透明质酸酶（HA）(245.98±35.78)mg/L，也显著低于重度酒精摄入组[LN (185.32±18.52)mg/L,PC-III(174.48±19.74)μg/L、IVC (231.64±27.45)μg/L和HA (289.74±20.36)mg/L]。结论 酒精及其摄入量是HCV感染患者肝功能恶化及肝纤维化进展的重要因素，对HCV感染患者的治疗需考虑酒精摄入量。更多还原

【Abstract】 Objective To explore the effects of different amount of alcohol consumption on liver function and liver fibrosis progression in hepatitis C patients.Methods Hepatitis C Patients treated in our hospital in recent one year and had disease courses of more than 10 years were selected.They were divided into mild alcohol intake group(20g-50g/d)and severe alcohol intake group(more than 50g/d)according to daily amount of alcohol consumption.Liver function and liver fibrosis indicators were detected and compared in both groups of patients.Results The levels of AST(115.12±12.14 U/L),ALT(121.83±11.21 U/L),total bilirubin(TBil)(84.95±6.21μmol/L)and gamma-glutamyl transferase(γ-GT)(72.31± 9.21 U/L)in mild alcohol intake group were significantly lower than those of AST(141.34±12.91 U/L)and ALT(145.57± 10.23 U/L),TBil(95.43 ± 5.38μmol/L)andγ-GT(85.48 ± 8.24 U/L)levels in severe alcohol intake group(P<0.05).Meanwhile,laminin(LN)(162.38 ± 21.34 mg/L),type III procollagen(PC-III)(146.74 ±23.43μg/L),type IV collagen(IV-C)(198.57± 30.34μg/L),Hyaluronidase(HA)(245.98 ± 35.78 mg/L)in mild alcohol intake group were significantly lower than those of LN(185.32±18.52 mg/L),PC-III(174.48±19.74μg/L),IV-C(231.64± 27.45μg/L)and HA(289.74± 20.36 mg/L)in the severe alcohol intake group.Conclusion Alcohol consumption are important factors associate with the deterioration of liver function and the progression of liver fibrosis in hepatitis C patients.The patients should be advised to limit alcohol intake for effectively treating liver disease.更多还原