【摘要】 声动力疗法(SDT)是一种利用声敏剂和低强度超声(US)结合治疗恶性肿瘤的新型无创治疗方法,SDT由光动力疗法(PDT)发展而来。由于超声波相对于光在组织中的传输深度更深,且声敏剂经过诱导而具有靶向性,同时还能利用超声波对声敏剂进行实时监测,所以SDT在肿瘤部位定位和激活深部组织内的敏化剂方面有着显著的优势。因此,与PDT相比,SDT可用于治疗范围更广、深度更深、不易接近的肿瘤。热疗(HT)作为一种辅助疗法应用于各种既定的癌症治疗,其机制是将载瘤组织的温度提高到40℃～43℃,使其发生不可逆的损伤。本文就SDT和HT在肿瘤治疗中参与的细胞信号调控机制以及SDT-HT联合疗法在肿瘤治疗中的应用进展进行综述。更多还原

【Abstract】 Sonodynamic therapy (SDT) is a new non-invasive treatment method that uses a combination of sono-sensitizers and low-intensity ultrasound (US) to treat malignant tumors.SDT is developed from photodynamic therapy (PDT).Because ultrasound can be transmitted deeper than light in tissues,sonosensitizers can be induced to be targeted,and sonosensitizers can be monitored in real time through ultrasound,SDT has significant advantages of locating the tumor site and activating the sensitizing agent in deep tissues.Therefore,compared with PDT,SDT can be used to treat tumors that are wider,deeper and more inaccessible.Hyperthermia (HT),as an adjuvant therapy,is applied to various established cancer treatments.Its mechanism is to increase the temperature of the tumor-bearing tissue to 40℃-43℃ to cause irreversible damage.This article reviews the cell signal regulation mechanism involved in SDT and HT in tumor therapy and the application progress of SDT-HT combination therapy on tumor.更多还原