【摘要】 <正>结核病（tuberculosis,TB）是由结核分枝杆菌（Mycobacterium tuberculosis,Mtb）感染引起的具有高致病性及死亡率的人畜共患传染病^[1]。作为一种胞内致病菌，Mtb通过气溶胶等途径感染肺部，随后被驻留在肺泡中的巨噬细胞识别、吞噬并发生复杂的相互作用^[2]。一方面，当Mtb感染巨噬细胞时，更多还原

【Abstract】 Tuberculosis(TB)is a zoonotic disease caused by Mycobacterium tuberculosis(Mtb)infection.The interaction between Mtb and the host immune system induces varieties of pathological changes in the lung. Granuloma is one of the main pathological features of TB with considerably complicated formation process. Matrix metalloproteinases(MMPs),a kind of secreted endopeptidases,are involved in the formation and immune regulation of pulmonary granulomas. Of note,MMPs participate in the immune regulation after Mtb infection,and the expression of MMPs is usually regulated by mitogen-activated protein kinases. MMPs modulate the inflammatory response in TB granuloma,and their expression affects the pathological changes of pulmonary granulomas after infection with Mtb. Inhibition of MMPs significantly reduces the granuloma formation. Inhibitors of MMPs used in the treatment of TB still need further exploration. Herein,this paper aims to provide theoretical basis for MMPs in the treatment of TB.更多还原