【摘要】 难溶性药物由于溶解性和溶出度较低，限制了其在体内的吸收分布，进而影响药物发挥药效，是药学研究的热点之一。固体分散体可以提高难溶性药物溶解度，采用喷雾干燥技术制备固体分散体，由于其良好的干燥效率和工艺重现性，近年来备受关注。本文对喷雾干燥的工艺步骤、设备类型及制备固体分散体常用聚合物等作一综述，并分析讨论了影响固体分散体关键质量属性的因素，探讨了喷雾干燥技术应用生产的困难和挑战。更多还原

【Abstract】 Due to the low solubility and dissolution of insoluble drugs, their absorption and distribution in the body are limited, which affects the drug efficacy. It is one of the research hotspots in the field of industrial pharmacy. Solid dispersion can improve the solubility of insoluble drugs. Spray drying technology is used to prepare solid dispersion, which has attracted much attention in recent years because of its high drying efficiency and good process reproducibility. This paper reviews the process steps, equipment types of spray drying and commonly used polymers for preparing solid dispersions. Based on the analysis of formulation and preparation technology, the factors affecting the critical quality attributes of solid dispersion are discussed, and the difficulties and challenges of spray drying technology in production application are discussed.更多还原