【摘要】 [目的]明确骨质疏松性椎体压缩骨折(OVCF)术后发生骨水泥渗漏的影响因素.[方法]利用计算机检索PubMed、Embase、Web of Science、The Cochrane Library、CNKI、万方数据库(时限为建库至2021年4月),采用NOS评分评价文献质量，应用RevMan 5.3分析软件进行Meta分析.[结果]共纳入18篇文献，提取14个影响因素.Meta分析结果显示，术前椎体高度[MD=-4.72,95%CI(-5.33,-4.12),P<0.01]、Cobb角[MD=1.20,95%CI(0.42,1.98),P=0.002]、椎体压缩程度[OR=2.63,95%CI(1.78,3.87),P<0.01]、周壁破坏[OR=4.29,95%CI(3.32,5.54),P<0.01]、终板损伤[OR=3.90,95%CI(2.14,7.10),P<0.01]、骨折至手术时间[MD=0.88,95%CI(0.19,1.56),P=0.01]、手术方式[OR=3.95,95%CI(2.06,7.54),P<0.01]、手术入路[OR=0.69,95%CI(0.52,0.92),P=0.01]、骨水泥注入量[MD=1.28,95%CI(1.06,1.49),P<0.01]及骨水泥黏度[OR=3.98,95%CI(2.23,7.12),P<0.01]与OVCF术后骨水泥渗漏均密切相关(P<0.05);年龄、性别、骨密度及手术部位与OVCF术后骨水泥渗漏未见有相关性(P>0.05).[结论]术前椎体高度、Cobb角、椎体压缩程度、周壁破坏、终板损伤、骨折至手术时间、手术方式、手术入路、骨水泥注入量及骨水泥黏度是OVCF术后骨水泥渗漏的影响因素.更多还原

【Abstract】 OBJECTIVE To determine the influencing factors of bone cement leakage after osteoporotic vertebral compression fracture(OVCF) surgery. METHODS PubMed, Embase, Web of Science, the Cochrane Library, CNKI and Wanfang databases were searched by computer(time limit was from the establishment of the database to April 2021). The quality of literatures was evaluated by NOS score. RevMan 5.3 software was used for Meta-analysis. RESULTS A total of 18 literatures were included and 14 influencing factors were extracted. Meta-analysis results showed that preoperative vertebral height [MD=-4.72, 95% CI(-5.33,-4.12), P<0.01], Cobb angle [MD=1.20, 95% CI(0.42, 1.98), P=0.002], vertebral compression degree[OR=2.63, 95% CI(1.78, 3.87), P<0.01], peripheral wall destruction [OR=4.29, 95% CI(3.32, 5.54), P<0.01], endplate injury [OR= 3.90, 95% CI(2.14, 7.10), P<0.01], time of fracture to operation [MD=0.88, 95% CI(0.19,1.56), P=0.01], operation method [OR= 3.95, 95% CI(2.06, 7.54), P<0.01], operation approach [OR= 0.69, 95% CI(0.52, 0.92), P=0.01], bone cement injection volume [MD=1.28, 95% CI(1.06, 1.49), P<0.01], and bone cement viscosity [OR=3.98, 95% CI(2.23, 7.12), P< 0.01] were associated with bone cement leakage after the surgery of OVCF(P<0.05). Age, gender, bone mineral density and surgical site were not associated with bone cement leakage after the surgery of OVCF(P>0.05). CONCLUSION Preoperative vertebral height, Cobb angle, vertebral compression degree, peripheral wall damage, endplate injury, time of fracture to operation, operation method, operation approach, bone cement injection volume, and bone cement viscosity are the influencing factors of bone cement leakage after the surgery of OVCF.更多还原