【摘要】 目的 本研究旨在探讨在抑郁症的协作照料策略下，通过在线支持小组（ISG）与计算机化认知行为疗法（CCBT）相结合治疗抑郁症的有效性，以及以这种方式提供CCBT是否比惯常治疗（UC）更有效。方法 招募45例抑郁症受试者，随机分为UC组、CCBT组和CCBT联合ISG组，采集一般人口学资料，给予相应的干预措施，并分别在干预1个月后、3个月后和6个月后采用评估员盲法对受试者进行9项患者健康问卷（PHQ-9）和12项简版健康问卷（SF-12）的评估。正态计量资料采用t检验，计数资料采用x~2检验。结果 与单纯接受CCBT治疗的患者相比，接受CCBT联合ISG干预的患者在6个月后的心理健康相关的生活质量改善方面差异不显著（P>0.05）。然而，与接受UC治疗的患者相比，CCBT组患者在6个月后的心理健康相关的生活质量有显著的改善（P<0.05）;6个月后PHQ-9的随访发现，UC组、CCBT组和CCBT联合ISG组，三组之间PHQ-9的评分差异无统计学意义（P>0.05）。结论 在抑郁症UC的基础上提供适当的ISG或（和）CCBT治疗，并不能显著改善抑郁症的预后，但CCBT可能可以有效提升抑郁症患者的心理健康相关的生活质量水平。更多还原

【Abstract】 Objective This study was conducted to explore the cooperative care strategy for depression by using internet support group(ISG and computerized cognitive behavioral therapy computerized cognitive behavioral therapy(CCBT). The effectiveness of CCBT in the treatment of depression and whether CCBT provided in this manner is more effective than usual care(UC). Methods 45 patients with depression were recruited and randomly divided into UC group, CCBT group and CCBT combined ISG group. General demographic data were collected and corresponding intervention measures were given. After 1 month, 3 months and 6 months of intervention, the 9-item patient health questionnaire(PHQ-9) and 12-item short-form health survey(SF-12) were evaluated by the blind method of evaluators. The t-test was used for normal measurement data, and the x~2 test was used for counting data. Results Compared with patients treated with CCBT alone, there was no significant difference in the improvement of mental health-related quality of life in patients treated with CCBT and ISG intervention after 6 months(P>0.05). However, compared with patients receiving UC, patients in CCBT group had significantly improved mental health-related quality of life after 6 months(P<0.05). The follow-up of PHQ-9 after 6months showed that there was no significant difference in PHQ-9 scores among the UC group, CCBT group and CCBT combined ISG group(P>0.05).Conclusion Appropriate ISG or(and) CCBT treatment on the basis of UC of depression can not significantly improve the prognosis of depression, but CCBT may effectively improve the level of mental health-related quality of life of patients with depression.更多还原