【摘要】 目的 探讨男性糖尿病患者血清 25- 羟基维生素 D₃[25-hydroxy vitamin D₃,25（OH）D₃] 与血清生殖激素水平的关系。方法 选取 2019 年 3 月—2020 年 8 月本院收治的男性糖尿病患者 130 例，将其按血脂水平分为观察组（68 例）及对照组（62例）。根据入组患者年龄将其分为 4 组（25 ～ 35 岁，36 ～ 45岁，46 ～ 55 岁及 56 ～ 65 岁），随后再次将入组患者依据血清25（OH）D₃水平将其分为 Q1、Q2 及 Q3 组。分别比较观察不同组别患者生殖激素及 25（OH）D₃等相关激素水平。结果 年龄段相同观察组患者 25（OH）D₃水平明显低于对照组，差异有统计学意义（P < 0.05）。随着年龄增长，观察组及对照组患者血清 25（OH）D₃水平均逐渐下降，且组间比较差异有统计学意义（P < 0.05）。Q3 组及 Q2 组睾酮水平明显高于 Q1 组，且 Q3 明显高于 Q2 组，差异均有统计学意义（P< 0.05），促卵泡激素与睾酮水平变化规律相反。血清 25（OH）D₃与睾酮水平呈正相关，与年龄、腰围、体质量指数等呈负相关（P < 0.05）。结论 男性血清 25（OH）D₃随着血脂及年龄的增高而不断下降，睾酮水平下降亦是 25（OH）D₃水平下降的伴随因素。更多还原

【Abstract】 Objective To investigate the relationship between serum 25-hydroxyvitamin D₃[25（OH）D₃] and serum reproductive hormone levels in men with dyslipidemia. Methods A total of 130male patients admitted to our hospital from March 2019 to August2020 were selected and divided into observation group （68 cases）and control group （62 cases） according to their blood lipid levels.According to the age of the enrolled patients, they were divided into 4 groups （25-35 years old, 36-45 years old,46-55 years old and56-65 years old）, and then the enrolled patients were again divided into groups based on serum 25（OH）D₃ For Q1, Q2 and Q3 groups.The levels of reproductive hormones, 25（OH）D₃ and other related hormones in different groups were compared and observed. Results The level of 25 （OH） D₃ in the observation group was significantly lower than that in the control group, and the difference was statistically significant （P < 0.05）. With the increase of age, the serum 25 （OH） D₃ level of the observation group and the control group gradually decreased, and the difference between the two groups was statistically significant （P < 0.05）. The levels of testosterone in Q3 and Q2 groups were significantly higher than those in Q1 group, and Q3 was significantly higher than that in Q2 group, the differences were statistically significant（P < 0.05）. Follicle stimulating hormone and testosterone levels change in the opposite way. Serum 25 （OH） D₃ was positively correlated with testosterone level, and negatively correlated with age, waist circumference and body mass index（P < 0 . 0 5 ） . Conclusion Male serum 25（OH） D₃ decreases continuously with the increase of blood lipids and age,and the decrease of testosterone level is also a concomitant factor of the decrease of 25（OH）D₃ level.更多还原