【摘要】 固体分散体通过“逆晶”原理可显著提高难溶性药物的溶解度和生物利用度。作为一类固体分散体辅料，介孔二氧化硅凭借其孔道实现“骨架逆晶”而提高药物的水溶性。此外，介孔二氧化硅内外表面可灵活修饰，赋予了该种载体在智能递药领域的诸多应用特性。因而，学者们对于介孔二氧化硅的生物学研究广为关注。本文就介孔二氧化硅作为固体分散体辅料方面的应用机理与优势作以简要综述。更多还原

【Abstract】 Solid dispersion can significantly improve solubility and bioavailability of insoluble drugs through the principle of“inverse crystal”. As a kind of excipient for solid dispersions,mesoporous silica improves drug water solubility by virtue of its pore channels to achieve“skeleton inverse crystal”. In addition,the internal and external surface of mesoporous silica can be modified flexibly,which endows the carrier with many application characteristics in the field of intelligent drug delivery.Therefore,the biological research of mesoporous silica is also widely concerned. The application mechanism and advantages of mesoporous silica as excipients for solid dispersions are reviewed in this paper.更多还原