【摘要】 目的:分析2型糖尿病（T2DM）男性患者性激素水平与体重指数（BMI）、糖脂代谢及胰岛素抵抗的相关性。方法:选取T2DM男性患者80例，根据BMI分别纳入T2DM肥胖组（55例，BMI≥28 kg/m²）和T2DM非肥胖组（25例，BMI<28 kg/m²）,另选择同时期男性体检健康者纳入对照组（50例）。分别比较三组一般资料、性激素指标[睾酮（T）、雌二醇（E₂）、雌二醇/睾酮比值（E₂/T）]、脂代谢指标[低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）、总胆固醇（TC）]、糖代谢指标[空腹血糖（FPG）、空腹胰岛素（FINS）、糖化血红蛋白（HbA1c）、胰岛素抵抗指数（HOMA-IR）]。采用Pearson法分析T2DM男性患者性激素水平与BMI、糖脂代谢指标及胰岛素抵抗的相关性。结果:T2DM肥胖组、T2DM非肥胖组、对照组BMI呈递减趋势（均P<0.05）。三组年龄比较差异无统计学意义（P>0.05）。T2DM肥胖组及T2DM非肥胖组T2DM病程比较差异无统计学意义（P>0.05）。T2DM肥胖组、T2DM非肥胖组、对照组血清T水平呈递增趋势，E₂和E₂/T水平呈递减趋势（均P<0.05）。T2DM肥胖组、T2DM非肥胖组、对照组血清HDL-C水平呈递增趋势，LDL-C水平呈递减趋势（均P<0.05）。T2DM肥胖组TC和TG水平高于其他两组（均P<0.05）。T2DM肥胖组、T2DM非肥胖组、对照组的FPG、FINS、HbA1c、HOMA-IR水平呈递减趋势（均P<0.05）。T2DM男性患者血清T与BMI、LDL-C、FPG、FINS、HbA1c、HOMA-IR呈负相关，与HDL-C呈正相关（均P<0.05）;E₂和E₂/T与BMI、LDL-C、FPG、FINS、HbA1c、HOMA-IR呈正相关，与HDL-C呈负相关（均P<0.05）。结论:T2DM男性患者血清T、E₂及E₂/T水平与BMI、糖脂代谢紊乱及胰岛素抵抗密切相关。更多还原

【Abstract】 Objective:To analyze the correlation between levels of sex hormones and body mass index（BMI）,glucolipid metabolism and insulin resistance in male patients with type 2 diabetes mellitus（T2 DM）.Methods:A total of 80 male patients with T2 DM were classified into T2 DM obesity group（55 cases, BMI higher than or equal to 28 kg/m²） and T2 DM non-obesity group（25 cases, BMI lower than 28 kg/m²） according to BMI,and the healthy male subjects in the same period were included in control group（50 cases）.The general data, sex hormones indicators（T,E₂,E₂/T）,lipid metabolism indicators（LDL-C,HDL-C,TG,TC） and glucose metabolism indicators（FPG,FINS,HbAlc, HOMA-IR） were compared among the three groups.Pearson method was used to analyze the correlation between sex hormone levels and BMI,glucolipid metabolism indexes and insulin resistance in male patients with T2 DM.Results:BMI of T2 DM obesity group, T2 DM non-obesity group and control group showed a decreasing trend（all P<0.05）.There was no significant difference in age among the three groups（P>0.05）.There was no significant difference in the course of T2 DM between T2 DM obesity group and T2 DM non-obesity group（P>0.05）.The serum T levels of T2 DM obesity group, T2 DM non-obesity group and control group showed an increasing trend, while E₂ and E₂/T levels showed a decreasing trend（all P<0.05）.The serum HDL-C level of T2 DM obesity group, T2 DM non-obesity group and control group showed an increasing trend, while the LDL-C level showed a decreasing trend（all P<0.05）.The levels of TC and TG in T2 DM obesity group were higher than those in other two groups（all P<0.05）.The levels of FPG,FINS,HbA1 c and HOMA-IR in T2 DM obesity group, T2 DM non-obesity group and control group showed a decreasing trend（all P<0.05）.Serum T in male patients with T2 DM was negatively correlated with BMI,LDL-C,FPG,FINS,HbA1 c, HOMA-IR,and positively correlated with HDL-C（all P<0.05）.E₂ and E₂/T were positively correlated with BMI,LDL-C,FPG,FINS,HbA1 c, HOMA-IR,and negatively correlated with HDL-C（all P<0.05）.Conclusion:Serum T,E₂ and E₂/T levels in male patients with T2 DM are closely related to BMI,glucolipid metabolism disorders and insulin resistance.更多还原