【摘要】 研究了锻造态Mg-Zn-Zr和Mg-Zn-Zr-Y镁合金在模拟体液中的p H值变化规律；按照ISO 10993的标准要求，分别制备了锻造态Mg-Zn-Zr/-Y合金不同浓度（100%、50%、10%）脐静脉血管内皮细胞（HUVEC）浸提液，通过体外溶血率测试了锻造态Mg-Zn-Zr/-Y镁合金的溶血率；通过CCK-8法体外细胞毒性试验及细胞形貌考察评价了锻造态Mg-Zn-Zr/-Y镁合金对HUVEC的细胞毒性。结果表明：锻造态Mg-Zn-Zr/-Y在SBF模拟体液中的腐蚀速度均高于纯镁的腐蚀速度；锻造态Mg-Zn-Zr镁合金溶血率为0.6%，锻造态Mg-Zn-Zr-Y镁合金溶血率为0.5%，不会导致严重溶血；锻造态Mg-Zn-Zr/-Y镁合金材料的浸提液浓度为10%时，对细胞的毒性较小，几乎不影响细胞的增殖。更多还原

【Abstract】 In this paper, the pH values of forged Mg-Zn-Zr/-Y magnesium alloys simulated body fluids(SBF) are studied. The forged Mg-Zn-Zr/-Y alloy is prepared with different concentrations(100%,50%,10%) human umbilical vein endothelial cell(HUVEC) extract according to the ISO 10993 standard, and the hemolysis rate of the forged magnesium alloy is measured by in vitro hemolysis rate. The forging state Mg-Zn-Zr/-Y isevaluated by CCK-8 in vitro cytotoxicity test and morphology observation cytotoxicity in HUVEC. The results show that the corrosion rate of forged Mg-Zn-Zr/-Y in SBF simulated body fluids is higher than that of pure magnesium. The hemolysis rate of Mg-Zn-Zr forged magnesium alloy is 0.6%, and which of forged Mg-Zn-Zr-Y magnesium alloy is 0.5%, indicating that forged magnesium alloy will not cause severe hemolysis. Forged Mg-Zn-Zr/-Y magnesium alloy materials with a concentration of 10%, the toxicity to cells is small.更多还原