【摘要】 目的:评价吲哚菁绿(Indocyanine green,ICG)介导的光动力疗法(Photodynamic therapy,PDT)(ICG-PDT)在治疗慢性牙周炎中的疗效。方法:检索EMBASE、Cochrane Library、Medline/PubMed、中国期刊全文数据库(CNKI)和中国生物医学文献数据库(CBM),截止时间2020年7月28日。筛选研究ICG-PDT治疗慢性牙周炎的随机对照试验(RCT),实验组采用ICG-PDT疗法,对照组采用单纯SRP治疗。结果:共纳入8项RCT,312例受试者。治疗3个月后,ICG-PDT组的探诊深度(PPD)、菌斑指数(PI)、临床附着丧失(CAL)改善均显著优于对照组,差异有统计学意义(P<0.05),但是在相对附着水平(RAL)、探诊出血(BOP)、牙龈退缩(GR)方面与对照组相比无明显差异(P>0.2);治疗6个月后,ICG-PDT组的PI、CAL改善情况均显著优于对照组,差异有统计学意义(P<0.05)。结论:ICG-PDT辅助SRP治疗慢性牙周炎效果显著优于传统的SRP治疗。更多还原

【Abstract】 Objective To evaluate the efficacy of indocyanine green (ICG) mediated photodynamic therapy (PDT) (ICG-PDT) in treating chronic periodontitis.Methods The EMBASE,Cochrane library,Medline/PubMed,CNKI,and CBM databases were searched up to 28th July 2020.Only randomized controlled trials (RCTs) were included.The test group received ICG-PDT combined with scaling and root planning (SRP),while the control group only received SRP.Results Eight RCTs involving 312 participants were included.The ICG-PDT group showed greater improvements referring probing pocket depth (PPD),plaque index (PI),clinical attachment loss (CAL) after 3 months than that of the control group (P<0.05).However,no significant differences between groups were observed for relative attachment level (RAL)、bleeding on probing (BOP) and gingival recession (GR) (P>0.2).After 6mouths,ICG-PDT group showed greater improvements referring PI,CAL when compared with the control group (P<0.05).Conclusion ICG mediated PDT provides additional benefits in treating chronic periodontitis than SRP alone.更多还原