【摘要】 目的：探讨肱踝脉搏波传导速度（baPWV）联合亚洲骨质疏松自我评估工具（OSTA）指数对中老年骨质疏松风险临床评估价值。方法：选取闽东畲族自然人群50岁及以上的中老年人212例作为研究对象，其中男98例，女114例，所有研究对象均接受了血液生化检查、baPWV检测、OSTA评估和腰椎双能X线扫描（DXA)。获取相关资料并绘制ROC工作曲线，评价baPWV联合OSTA进行骨质疏松风险性评估的可行性，并确定适当的高危指标。结果 ：以DXA作为金标准，联合baPWV与OSTA对闽东畲族中老年人进行骨质疏松风险评估时，拟回归方程Y=-2.222-0.272×OSTA+0.114×baPWV，其高危指标Y>-1.169 4，预测值与DXA诊断结果的ROC的曲线下面积0.890，标准误为0.022,P为0.000，并联baPWV和OSTA进行骨质疏松风险评估，以baPWV≥16.87 m/s或OSTA≤-3.2其中之一为高危指标，其敏感度为95.3%，特异度为74.3%，约登指数为0.69。结论：联合baPWV与OSTA可初步评估中老年人骨质疏松风险性，选择适当的高危指标，可获得较满意的敏感度和特异度，其具有较好的临床应用前景。更多还原

【Abstract】 Objective: To explore the clinical value of brachial-ankle pulse wave velocity(baPWV) combined with the osteoporosis self-assessment fool for Asians(OSTA) index in the preliminary assessment of osteoporosis risk in the middle-aged and elderly patients. Methods: A total of two hundred and twelve middle-aged and elderly people(over the age of 50) in the natural population of the She minority in eastern Fujian as research objects were selected, including 98 males and 114 females. All the research objects received blood biochemical examination, baPWV detection, OSTA evaluation and lumbar dualenergy X-ray scan(DXA). The ROC working curve was drawn with the relevant data obtained from the study. It was used to evaluate the feasibility of combined baPWV and OSTA for assessing osteoporosis risk and determining the appropriate cut-off value. Results: Using DXA as the gold standard, the risk of osteoporosis was assessed in the middle-aged and elderly of the She minority in eastern Fujian while combining baPWV and OSTA. The regression curve was fitted as Y=-2.222-0.272×OSTA+0.114×baPWV, the high-risk index Y>-1.169 4. Meanwhile, the area under the ROC(AUC) which was drawn by the predicted value and DXA screening result was 0.890, the standard error was 0.022, and the P was 0.000. When the baPWV and OSTA were used parallelly to evaluate the osteoporosis risk, it could achieve the efficiency of risk assessment, with a sensitivity of95.3%, a specificity of 74.3%, and a Youden index of 0.69, using the high-risk index set by baPWV ≥16.87 m/s or OSTA index≤-3.2. Conclusion: Combined baPWV and OSTA could assess the risk of osteoporosis in the middle-aged and elderly preliminarily. The selection of appropriate high-risk indicators can result in satisfactory sensitivity and specificity, and its clinical application has a better prospect.更多还原