【摘要】 目的:系统评价运动疗法对血透不宁腿综合征(RLS)的疗效。方法:依据PICOS原则，通过检索中文或英文相关运动治疗血透患者不宁腿综合征的随机对照研究，检索年限2008年01月01日—2021年06月30日。按照纳入标准和排除标准筛选有关文献，使用Cochrane风险偏倚工具对纳入研究的有效性进行评估，采用Review Manager 5.3版本软件进行统计分析。结果:共纳入6项临床随机对照研究，Meta分析显示：(1)运动疗法可以显著改善血透RLS患者的RLS量表积分，与对照组相比，差异具有统计学意义(WMD=4.19,95%CI:-13.7～-4.97,P<0.000 1);(2)运动疗法可以改善血透患者生活质量，与对照组相比，差异有统计学意义(WMD=3.57,95%CI:9.67～33.23,P=0.000 4);(3)同样，运动疗法也可以改善血透患者抑郁评分，改善抑郁情绪，与对照组相比，差异有统计学意义(WMD=2.55,95%CI:-14.06～-1.85,P=0.01);(4)运动疗法还可以改善血透患者的睡眠质量，与对照组相比，差异有统计学意义(WMD=2.09,95%CI:-5.24～-0.16,P=0.04)。结论:通过Meta分析显示，运动可以有效改善血透RLS患者的RLS量表积分、生活质量、抑郁评分及睡眠质量。建议将来可以进一步观察不同的运动形式对不同的血透RLS患者的疗效，以便探索出提高血透患者生活质量的更优的运动方式。更多还原

【Abstract】 Objective:The efficacy of exercise therapy on restless legs syndrome(RLS) in hemodialysis patients was systematically evaluated. Methods:The WanFang database, CNKI, VIP database, PubMed, Cochrane library, EMBASE were searched for randomized controlled trials(RCTs) from January 1, 2008 till June 30, 2021. The effectiveness of included studies was evaluated using the Cochrane risk bias tool, and statistical analysis was performed using Review Manager version 5.3 software. Results:A total of 6 RCTs were included. Meta-analysis showed that(1) exercise therapy significantly improved the RLS scale scores of RLS patients with hemodialysis, showing significant differences between the exercise group and control group(WMD=4.19, 95%CI:-13.7～-4.97, P<0.000 1);(2) exercise therapy improved the quality of life of hemodialysis patients, showing significant differences between the exercise group and control group(WMD=3.57, 95%CI:9.67～33.23, P=0.000 4);(3) similarly, exercise therapy improved the depression scores and improved the mood of patients with hemodialysis. Compared with the control group, a statistical difference was observed(WMD=2.55, 95%CI:-14.06～-1.85, P=0.01);(4) exercise therapy also significantly improved the sleep quality of hemodialysis patients when compared with the control group(WMD=2.09, 95%CI:-5.24～-0.16, P=0.04). Conclusion:These results showed that exercise can effectively improve the RLS scale points, quality of life, depression score, and sleep quality of in RLS patients with hemodialysis. This suggested that the efficacy of different forms of exercise on different hemodialysis patients with RLS can be further observed in the future to explore appropriate exercise therapy for improving the quality of life of hemodialysis patients.更多还原