【摘要】 本文设计并合成了23个含酰胺结构单元的新型喹唑啉酮类化合物，经¹H NMR、¹³C NMR和HRMS确证结构。在100μg·mL^-1和50μg·mL^-1浓度下，评价了它们对水稻白叶枯病菌、猕猴桃溃疡病菌和柑橘溃疡病菌的抑菌活性。结果表明，化合物对柑橘溃疡病菌有较强的抑制活性，并测定了6个化合物对柑橘溃疡病菌的EC₅₀值。其中，活性最优化合物1-（4-氟苯基）-3-（4-（（3-甲基-4-氧代-3,4-二氢喹唑啉-2-基）甲氧基）苯基）尿素（4i）对柑橘溃疡病菌的抑菌活性优于阳性对照，达到8.98μg·mL^-1。更多还原

【Abstract】 Twenty-three quinazolinones containing amide units were designed and synthesized.Their structures were confirmed by ¹H NMR,¹³C NMR,and HRMS.All these compounds were evaluated for antibacterial activities against Xanthomonas oryzae（Xoo）,Pseudomonas syringae（Psa）and Xanthomonas axonopodis（Xac）at 100 μg·mL^-1 and 50 μg·mL^-1 respectively.The results indicated that these compounds performed well activities against Xac.The EC₅₀ values of the best six compounds against Xac were tested.In particular, 1-（4-fluorophenyl）-3-（4-（（3-methyl-4-oxo-3,4-dhydroquinazolin-2-yl）methoxy）phenyl）urea（4 i）showed much higher antibacterial activity against Xac than positive control, which was reached to 8.98 μg·mL^-1.更多还原