【摘要】 目的 探讨消炎宣肺汤联合西医治疗对肺炎喘嗽(痰热闭肺型)患儿炎症反应、免疫功能的影响及其治疗效果。方法 选取2019年7月至2021年6月在湛江市第一中医医院就诊的肺炎喘嗽(痰热闭肺型)患儿126例，采用随机数表法分为两组，各63例。对照组采用西医常规治疗，观察组采用消炎宣肺汤口服联合西医常规治疗，治疗2周后比较炎症指标[白细胞介素(IL)-6、IL-10、C反应蛋白(CRP)]、免疫功能指标[CD4~+/CD8~+比值、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)]、临床疗效及不良反应发生情况。结果 治疗后，观察组血清IL-6、CRP水平低于对照组，CD4~+/CD8~+比值、IgG、IgM及IL-10水平高于对照组，差异均有统计学意义(P<0.05)。治疗后，观察组发热、咳嗽、气喘、胸部X线片病变吸收、肺部湿啰音等症状体征消失时间较对照组明显缩短(P<0.05);总有效率明显高于对照组(96.82%vs.77.78%,P<0.05),总不良反应发生率明显低于对照组(4.76%vs.20.63%,P<0.05)。结论 消炎宣肺汤联合西医治疗可提高小儿肺炎喘嗽的临床疗效及免疫功能，并减轻机体炎症反应程度，且安全性良好。更多还原

【Abstract】 Objective To investigate the effect of Xiaoyan Xuanfei Decoction combined with western medicine on the inflammatory reaction and immune function in child patients with pneumonia asthma and cough(phlegm-heat closed lung type) and its treatment efficacy.Methods A total of 126 child patients with pneumonia asthma and cough(phlegm heat closed lung type) treated in Zhanjiang Municipal First Hospital of Traditional Chinese Medicine from July 2019 to June 2021 were selected and divided into the two groups by using the random number table method, 63 cases in each group.The control group was treated with the western medicine routine treatment, while the observation group adopted oral Xiaoyan Xuanfei Decoction combined with western medicine routine treatment.The inflammatory indicators [interl eukin(IL)-6,IL-10,C-reactive protein(CRP)],immune function indicators [CD4~+/CD8~+ratio, immunoglobulin G(IgG),immunoglobulin M(IgM)],clinical efficacy and adverse reactions after 2-week treatment were compared between the two groups.Results The serum levels of IL-6 and CRP after treatment in the observation group were lower than those in the control group, the CD4~+/CD8~+ ratio and levels of IgG,IgM and IL-10 in the observation group were higher than those in the control group, and the differences were statistically significant(P<0.05).The disappearance time of fever, cough, asthma, chest X-ray lesion absorption and wet pulmonary moist rales after treatment in the observation group was significantly shortened compared with those in the control group(P<0.05).The total effective rate of the observation group was higher than that of the control group(96.82% vs. 77.78%,P<0.05),and the total incidence rate of adverse reactions of the observation group was lower than that of the control group(4.76% vs. 20.63%,P<0.05).Conclusion Xiaoyan Xuanfei Decoction combined with western medicine could increase the clinical efficacy and immune function in treating child pneumonia cough and asthma, alleviate the degree of inflammatory reactions, moreover, has good safety.更多还原