【摘要】 为研究不同来源燕麦对高脂饲喂的ApoE^-/-小鼠降血脂功能的影响，将40只雄性ApoE^-/-小鼠按照平均体重随机分为5组，即常规饮食（Chow）组、高脂饮食（HFD）组、燕麦1组（OAT-1）、燕麦2组（OAT-2）以及燕麦3组（OAT-3），每组8只。实验0 w、4 w、8 w、12 w时，分别测定小鼠血清总胆固醇（total cholesterol，TC）、LDL胆固醇（LDL cholesterol，LDL-c）、甘油三酯（triglycerides，TG）、HDL胆固醇（HDL cholesterol，HDL-c）和VLDL胆固醇（VLDL cholesterol，VLDL-c）水平；12 w后同时观察肝组织损伤变化情况。其中，3组燕麦组均能够显著减少ApoE^-/-小鼠血清中TC、LDL-c、TG和VLDL-c的含量，说明3组燕麦均具有良好的降血脂作用，OAT-3组降血脂效果更加明显。病理学检测结果显示，3组燕麦组均具有减少高脂饲喂的ApoE^-/-小鼠肝脏中脂质沉积的作用。燕麦饲喂后对高脂饲喂的ApoE^-/-小鼠具有显著降低血脂及降低肝损伤作用。更多还原

【Abstract】 In order to study the effects of oats from different sources on the hypolipidemic function of high-fat-fed ApoE^-/-mice,40 male ApoE^-/-mice were randomly divided into 5 groups of 8 mice each with mean body weight,which were normal control group （Chow）,high-fat model group （HFD）,oat 1 group （OAT-1）,oat 2 group （OAT-2） and oat 3 group （OAT-3）.The total cholesterol （TC）,LDL cholesterol （LDL-c）,triglycerides （TG）,HDL cholesterol （HDL-c） and VLDL cholesterol （VLDL-c） levels in serum of mice were measured respectively,after 0,4,8 and 12 weeks,and the changes of liver injury were observed after 12 weeks.The serum levels of TC,LDL-c,TG and VLDL-c in ApoE^-/-mice were significantly reduced in the three oat groups,indicating that the three oat groups have good effects on the hypolipidemic function in ApoE^-/-mice,and the OAT-3 group decreased the serum lipid contents more than OAT-1 group.The pathological examination results showed that the three oat groups all had the effect of reducing lipid deposition in the liver of high-fat-fed ApoE^-/-mice.Oats can significantly reduce blood lipids and liver injury in high-fat-fed ApoE^-/-mice.更多还原