【摘要】 脑膜转移是指恶性肿瘤发生远处转移累及至脑膜,分为硬脑膜转移及软脑膜转移。随着乳腺癌患者生存期的延长,脑膜转移的发生率逐渐升高。由于预后较差,脑膜转移患者被大多数临床试验排除,以致缺少早期诊断方法及标准治疗方案,成为亟待解决的临床问题。近年来,研究者对脑膜转移机制的认识逐渐加深,脑脊液循环肿瘤细胞及游离肿瘤DNA等诊断技术逐步发展,脑膜转移治疗相关的临床试验陆续开展,使得乳腺癌脑膜转移的管理有所突破。本文就乳腺癌脑膜转移的发生机制、诊断方法及治疗进展做一综述。更多还原

【Abstract】 Meningeal metastasis refers to the distant metastasis of malignant tumor to the meninges,which can be divided into dural metastasis and leptomeningeal metastasis. With the prolongation of survival of patients with advanced breast cancer, the incidence of meningeal metastasis increases gradually. Due to the poor prognosis, meningeal metastasis patients are often excluded by most clinical trials, which leads to the lack of guidelines for early diagnosis and standard treatment, and makes it become an urgent clinical problem to be solved. In recent years, researchers have deepened their understanding of the mechanism of meningeal metastasis, diagnostic techniques such as circulating tumor cells and free tumor DNA in cerebrospinal fluid have been gradually developed, and clinical trials related to meningeal metastasis treatment have been carried out, which has resulted in a breakthrough in the management of meningeal metastasis of breast cancer. In this paper, we discuss the mechanism, diagnosis, and treatment of breast cancer meningeal metastasis.更多还原