【摘要】 结核病耐药和传播监测能够为公共卫生决策提供重要信息。结核分枝杆菌全基因组测序(whole genome sequencing,WGS)分析在耐药检测和传播鉴定上比传统表型药物敏感性试验方法和基因分型方法具有更大优势,在发达国家已经应用。全基因组数据分析平台SAM-TB的建立使得构建基于结核分枝杆菌WGS的全国结核病耐药和传播监测数据库成为可能。笔者建议目前以省为单位,逐步推进这项工作,最终形成覆盖全国的结核病耐药和传播监测网络。更多还原

【Abstract】 The surveillance of tuberculosis drug-resistance and transmission provide important information to making up public health policies.Whole genome sequencing(WGS)of Mycobacterium tuberculosis(MTB)has an advantage over the traditional phenotypic drug susceptibility test and genotyping in drug resistance detection and transmission identification,and has been introduced into the health system of some developed countries.The establishment of the WGS data analysis platform,SAM-TB,makes it possible to construct a national tuberculosis drug-resistance and transmission surveillance database base on MTB WGS data.The authors suggest that this work should be carried out step by step at the provincial level,and finally a nationwide surveillance network of tuberculosis drug resistance and transmission can be formed.更多还原